INT332610

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpp4) extracellular region (Dpp4) cell adhesion (Dpp4)
Golgi apparatus (Dpp4) endoplasmic reticulum (Dpp4) plasma membrane (Dpp4)
Anatomy Link Frequency
beta cell 2
Dpp4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 90.44 High High
tolerance 14 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 190 99.92 Very High Very High Very High
Hypoglycemia 58 90.28 High High
Weight Loss 4 87.72 High High
Obesity 20 70.16 Quite High
Insulin Resistance 32 59.16 Quite High
Stress 2 55.24 Quite High
Weight Gain 12 51.68 Quite High
Congenital Anomalies 8 35.12 Quite Low
Overweight 4 27.44 Quite Low
Hyperglycemia 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DPP-4 inhibitors augment beta cell function and simultaneously reduce elevated plasma glucagon levels in T2DM patients.
Positive_regulation (augment) of Negative_regulation (inhibitors) of DPP-4 in beta cell associated with diabetes mellitus
1) Confidence 0.19 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.94 Pain Relevance 0.05
The glucoregulatory mechanisms by which GLP-1 and exenatide/liraglutide act are similar, but GLP-1 suppresses gastric acid secretion, whereas exenatide and liraglutide do not.10 DPP-4 inhibitors augment insulin secretion and inhibit glucagon release, but do not slow gastric emptying and are weight neutral.11
Positive_regulation (augment) of Negative_regulation (inhibitors) of DPP-4
2) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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