INT332635

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.94
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) signal transduction (Glp1r) extracellular region (Gcg)
plasma membrane (Glp1r) cytoplasm (Gcg) signal transducer activity (Glp1r)
Anatomy Link Frequency
alpha cell 2
Glp1r (Mus musculus)
Gcg (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 77.76 Quite High
tolerance 14 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 58 97.84 Very High Very High Very High
Diabetes Mellitus 190 96.68 Very High Very High Very High
Hyperglycemia 22 82.32 Quite High
Insulin Resistance 32 68.64 Quite High
Apoptosis 2 52.44 Quite High
Obesity 20 45.44 Quite Low
Overweight 4 41.80 Quite Low
Congenital Anomalies 8 34.36 Quite Low
Weight Gain 12 25.04 Quite Low
Atherosclerosis 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the effects of GLP-1 on insulin and glucagon secretion wane as the fasting glucose level returns to normal, hypoglycemia is minimized in T2DM patients treated with GLP-1-based therapy.
GLP-1 Regulation (effects) of Localization (secretion) of glucagon associated with hypoglycemia and diabetes mellitus
1) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.52 Pain Relevance 0.04
The main physiologic role of glucagon is to oppose the action of insulin on HGP in order to protect against hypoglycemia and restore normoglycemia.111 GLP-1 inhibits the inappropriately high glucagon secretion after a meal, both directly through the GLP-1 receptor on the alpha cell and indirectly by stimulating insulin secretion, although the absolute contribution of each component is still debated.112 This glucose-dependent inhibitory effect of GLP-1 on glucagon secretion reduces HGP and decreases postprandial plasma glucose levels.113

Correction of accelerated gastric emptying

GLP-1 Regulation (effect) of Localization (secretion) of glucagon in alpha cell associated with hypoglycemia
2) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.42 Pain Relevance 0

General Comments

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