INT332638

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.47
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Glp1r) plasma membrane (Glp1r) signal transducer activity (Glp1r)
cytoplasm (Gip)
Anatomy Link Frequency
beta cell 1
Gip (Mus musculus)
Glp1r (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 7 97.26 Very High Very High Very High
Inflammation 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 95 98.88 Very High Very High Very High
Impaired Glucose Tolerance 6 97.26 Very High Very High Very High
Weight Loss 2 84.08 Quite High
Hypoglycemia 29 45.84 Quite Low
Cardiovascular Disease 3 33.28 Quite Low
Apoptosis 1 11.76 Low Low
Insulin Resistance 16 5.00 Very Low Very Low Very Low
Hyperglycemia 11 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low
Atherosclerosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As individuals progress from normal glucose tolerance to IGT to T2DM, stimulated GLP-1 levels decline89,90 (Figure 7), and there is beta cell resistance to the glucose-dependent stimulatory effect of both GLP-1 and GIP on insulin secretion.91 In T2DM the contribution of incretin hormones to the insulin response has been estimated to be reduced to about 36% in T2DM subjects.86,92 From the therapeutic standpoint, one can increase circulating GLP-1 levels by administering a GLP-1 analog that is resistant to DPP-4 degradation or by giving a DPP-4 inhibitor.7,93,94
GIP Regulation (effect) of GLP-1 in beta cell associated with diabetes mellitus, tolerance and impaired glucose tolerance
1) Confidence 0.02 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.47 Pain Relevance 0.05

General Comments

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