INT332684

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.11
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1, Lep) extracellular region (Edn1, Lep) intracellular (Lep)
lipid metabolic process (Lep) cell-cell signaling (Edn1) cytoplasm (Edn1)
Edn1 (Rattus norvegicus)
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 7 85.96 High High
Inflammation 5 21.40 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 12 100.00 Very High Very High Very High
Stress 15 99.44 Very High Very High Very High
Cardiovascular Disease 11 97.76 Very High Very High Very High
Aging 6 87.84 High High
Hypertension 6 80.32 Quite High
Pressure And Volume Under Development 18 77.24 Quite High
Nicotine Addiction 2 70.88 Quite High
Increased Venous Pressure Under Development 27 66.56 Quite High
Hyperlipidemia 11 37.44 Quite Low
Obesity 7 35.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tone of the coronary arteries is critically dependent on an activation of ET receptors and an increased ET-1 associates with a proportional decrease in NO accompanying coronary endothelial dysfunction.46 Vascular abnormalities resulting from over-expression of endothelin receptor, leptin, and NOX and stress contribute to an increased risk of CVD (cardiovascular disease).
ET-1 Binding (associates) of leptin associated with stress, cardiovascular disease and congenital anomalies
1) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.11 Pain Relevance 0.04

General Comments

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