INT332689

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) extracellular space (Edn1)
extracellular region (Edn1) plasma membrane (Ros1) cell-cell signaling (Edn1)
Anatomy Link Frequency
vasculature 1
Edn1 (Rattus norvegicus)
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 2 98.58 Very High Very High Very High
Kinase C 10 95.70 Very High Very High Very High
Bioavailability 5 92.56 High High
Inflammation 5 24.72 Low Low
antagonist 7 15.04 Low Low
cva 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 94.44 High High
Diabetes Complications 3 93.98 High High
Diabetes Mellitus 29 89.96 High High
Parkinson's Disease 1 65.96 Quite High
Hyperglycemia 9 60.36 Quite High
Stress 15 56.64 Quite High
Congenital Anomalies 12 49.36 Quite Low
Insulin Resistance 3 45.96 Quite Low
Uterine Fibroids 1 35.12 Quite Low
Disease 2 33.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In diabetes, ET-1 levels are elevated and upregulation of ETA and ETB occurs in the vasculature, along with a reduction in NO bioavailability.1,4 Activated ET receptors can also be found in diabetic complications such as cardiomyopathy and testopathy.24–26 NOX is stimulated mainly by ETA, with PKC actively involved.27 The vasoconstrictive activity of ET-1 is mediated by the activity of NOX, and an activation of the L-type calcium channels by ET-1 causes an influx of calcium ions through activating NOX.28 An interaction of ET-1 with ROS is known as the ET–ROS pathway, which activates the ERK signaling pathway and AP-1 transcriptional factor.29 There is a positive feedback mechanism between them via an activation of ERK.
ET-1 Binding (interaction) of ROS in vasculature associated with kinase c, diabetes complications, diabetes mellitus, calcium channel, coronary heart disease and bioavailability
1) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.71 Pain Relevance 0.14

General Comments

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