INT3327

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Context Info
Confidence 1.00
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.96
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
cleavage 4
pancreas 2
neutrophils 1
PRSS1 (Homo sapiens)
PRSS1 - E79K (1)
Pain Link Frequency Relevance Heat
Enkephalin 29 99.72 Very High Very High Very High
tolerance 1 99.54 Very High Very High Very High
Chronic pancreatitis 783 99.42 Very High Very High Very High
Dynorphin 7 98.48 Very High Very High Very High
Catecholamine 3 96.04 Very High Very High Very High
methotrexate 4 96.00 Very High Very High Very High
cytokine 17 92.16 High High
Inflammation 72 91.80 High High
metalloproteinase 46 78.28 Quite High
Glutamate 5 72.68 Quite High
Disease Link Frequency Relevance Heat
Autolysis 12 100.00 Very High Very High Very High
Pancreatitis 1013 99.42 Very High Very High Very High
Urinary Tract Infection 26 98.96 Very High Very High Very High
Disease 196 97.36 Very High Very High Very High
Breast Cancer 68 96.80 Very High Very High Very High
Pheochromocytoma 2 92.28 High High
INFLAMMATION 69 91.80 High High
Stress 39 87.32 High High
Cancer 86 87.04 High High
Adhesions 1 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Current opinion on the pathogenesis of hereditary pancreatitis suggests that the mutations lead to increased trypsin activity in the pancreatic tissue as a result of enhanced autoactivation of trypsinogen or decreased autocatalytic degradation (autolysis) of trypsin.
Protein_catabolism (degradation) of trypsin associated with autolysis and pancreatitis
1) Confidence 1.00 Published 2001 Journal Orv Hetil Section Abstract Doc Link 11324217 Disease Relevance 0.65 Pain Relevance 0.08
Biochemical characterization of the N29I mutation using recombinant trypsinogen found no effect on trypsin or trypsinogen stability.
Protein_catabolism (stability) of trypsin
2) Confidence 0.98 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.20 Pain Relevance 0
David Whitcomb proposed that the Arg122-Val123 autolytic peptide bond in trypsin plays an important role in the degradation of prematurely activated trypsin in the pancreas.
Protein_catabolism (degradation) of trypsin in pancreas
3) Confidence 0.98 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.59 Pain Relevance 0.14
Biochemical characterization of the N29I mutation using recombinant trypsinogen found no effect on trypsin or trypsinogen stability.
Protein_catabolism (stability) of trypsinogen
4) Confidence 0.98 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.20 Pain Relevance 0
The autodegradation kinetic of the mutated trypsin sequence was measured by a novel fluorescence resonance energy transfer (FRET) assay using designed 11 amino acid peptides from PRSS1 aa 118-aa 127 containing the trypsin cleavage site at aa 122 coupled to a Dabcyl/EDANS FRET system.
Protein_catabolism (autodegradation) of trypsin in cleavage
5) Confidence 0.89 Published 2008 Journal J. Med. Genet. Section Body Doc Link 18511571 Disease Relevance 0.08 Pain Relevance 0
A study using cerulein-induced zymogen activation in isolated rat acini demonstrated that autodegradation of trypsin mitigates cathepsin B-mediated trypsinogen activation, suggesting that a failsafe mechanism might be indeed operational in the mammalian pancreas [64].
Protein_catabolism (autodegradation) of trypsin in pancreas
6) Confidence 0.87 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.37 Pain Relevance 0.07
Although the E79K mutation introduces a potential new tryptic cleavage site, autocatalytic degradation (autolysis) of E79K-trypsin was also unchanged.
Protein_catabolism (degradation) of trypsin (E79K) in cleavage associated with autolysis
7) Confidence 0.86 Published 2004 Journal Hum. Mutat. Section Abstract Doc Link 14695529 Disease Relevance 0.71 Pain Relevance 0.11
Proteolysis of human trypsinogen 1.
Protein_catabolism (Proteolysis) of trypsinogen 1
8) Confidence 0.66 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 6696753 Disease Relevance 0.25 Pain Relevance 0.25
These results show that the major protein present in pancreatic precipitates (and pancreatic stones) of patients with chronic pancreatitis is a degradation product of trypsinogen 1 liberated by a proteolysis which necessarily requires a premature zymogen activation in the disease.
Protein_catabolism (proteolysis) of trypsinogen 1 associated with disease and chronic pancreatitis
9) Confidence 0.66 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6696753 Disease Relevance 0.36 Pain Relevance 0.26
Thus, the pleiotropic biochemical effect of R122H raises the possibility that the pathogenic alteration is unrelated to trypsin stability.
Protein_catabolism (stability) of trypsin
10) Confidence 0.65 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.22 Pain Relevance 0
R122H and increased trypsin stability
Protein_catabolism (stability) of trypsin
11) Confidence 0.65 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.59 Pain Relevance 0.15
The N29T mutant, firstly described by Pfützer et al. in 2002, exhibited a phenotype similar to that of R122H, both increased trypsin stability and enhanced autoactivation were documented [11,64].
Protein_catabolism (stability) of trypsin
12) Confidence 0.65 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.32 Pain Relevance 0
More importantly, the model fails to explain how the other pancreatitis associated PRSS1 mutations might work, as the majority of these do not affect trypsin stability.


Protein_catabolism (stability) of trypsin associated with pancreatitis
13) Confidence 0.65 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.21 Pain Relevance 0
Enkephalin immunoreactivity was not contained in purified chromogranin A, either before or after trypsin cleavage.
Protein_catabolism (cleavage) of trypsin in cleavage associated with enkephalin
14) Confidence 0.50 Published 1988 Journal J. Hypertens. Section Abstract Doc Link 3361117 Disease Relevance 0.09 Pain Relevance 1.48
The main dynorphin A peak at 5 kdalton was transferred to a major Leu-enkephalin-Arg6 peak by trypsin degradation.
Protein_catabolism (degradation) of trypsin associated with dynorphin and enkephalin
15) Confidence 0.39 Published 1986 Journal Brain Res. Section Abstract Doc Link 2870778 Disease Relevance 0 Pain Relevance 0.81
Mesotrypsin (PRSS3) can degrade intrapancreatic trypsin inhibitors that protect against CP.
Protein_catabolism (degrade) of trypsin associated with chronic pancreatitis
16) Confidence 0.18 Published 2010 Journal Pancreatology Section Abstract Doc Link 20484962 Disease Relevance 0.37 Pain Relevance 0.46
-trypsin inhibitors are degraded by neutrophilic elastases [18].
Protein_catabolism (degraded) of trypsin
17) Confidence 0.09 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876852 Disease Relevance 0.80 Pain Relevance 0.09
In excess, the magnitude of which varies among individuals, trypsin at first produces activation and later a decline in PRA, probably due to degradation of the reactants (prorenin, renin, angiotensinogen) and of the initial product (angiotensin I).
Protein_catabolism (degradation) of trypsin
18) Confidence 0.06 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 709420 Disease Relevance 0 Pain Relevance 0
The fibrillar integrity of the collagen layer was confirmed by incubation with collagenase that degraded the film whilst the collagen fibres were resistant to degradation by both trypsin and plasmin (data not shown).
Protein_catabolism (degradation) of trypsin
19) Confidence 0.05 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0.71 Pain Relevance 0.10
This endogenous enzyme is normally inactive until trypsin proteolysis of its propeptide, but a mutant form (CPAST3), activated by ubiquitously expressed intracellular propeptidases, has similar prodrug activating properties [109].
Protein_catabolism (proteolysis) of trypsin
20) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.16 Pain Relevance 0.24

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