INT332792

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.61
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
Anatomy Link Frequency
spinal cord 2
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 39 100.00 Very High Very High Very High
Thermal hyperalgesia 14 99.58 Very High Very High Very High
spinal dorsal horn 2 92.32 High High
Osteoarthritis 36 91.20 High High
rheumatoid arthritis 74 90.88 High High
Hyperalgesia 17 89.16 High High
Inflammation 34 88.64 High High
chemokine 1 87.44 High High
Analgesic 5 83.16 Quite High
cytokine 8 79.44 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 72 99.84 Very High Very High Very High
Hyperalgesia 31 99.58 Very High Very High Very High
Myelofibrosis 30 97.84 Very High Very High Very High
Apoptosis 77 97.12 Very High Very High Very High
Hypersensitivity 13 94.96 High High
Aggression 4 93.12 High High
Frailty 38 91.20 High High
Rheumatoid Arthritis 74 90.88 High High
Cancer 61 90.52 High High
INFLAMMATION 39 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the inhibition of class I HDAC with MS-275 showed no effect on CFA-induced thermal hyperalgesia and in addition the expression of this class of HDACs in the spinal cord was not induced by CFA.


Neg (not) Positive_regulation (induced) of Gene_expression (expression) of HDAC in spinal cord associated with thermal hyperalgesia and spinal cord
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 1.07 Pain Relevance 0.87
significantly increased nuclear HDAC activity in RASFs (n = 3) and peaked at 6 h (P = 0.0001 vs 0 and 24 h) (Figure 5a), indicating that TNF?
Positive_regulation (increased) of Gene_expression (activity) of HDAC
2) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.76 Pain Relevance 0.38
Class I HDAC is overexpressed in gastric cancer patients [57,58].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HDAC associated with stomach cancer
3) Confidence 0.15 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.73 Pain Relevance 0.11
Chromatin remodeling is physiologically regulated by two enzymes, histone acetyltransferase (HAT) and histone deacetylase (HDAC).
Positive_regulation (histone acetyltransferase) of Gene_expression (histone acetyltransferase) of HDAC
4) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.78 Pain Relevance 0
Wang et al., (2008) demonstrated increased HDAC levels in the CD34-positive cell fractions of patients with PMF [30].
Positive_regulation (increased) of Gene_expression (levels) of HDAC associated with myelofibrosis
5) Confidence 0.10 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.26 Pain Relevance 0.08

General Comments

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