INT332795

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.64
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) mitochondrion (Vhl) extracellular matrix organization (Vhl)
signal transducer activity (Cxcr4) cytoplasm (Vhl) cytosol (Vhl)
Vhl (Rattus norvegicus)
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1 95.64 Very High Very High Very High
cytokine 7 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 100.00 Very High Very High Very High
Von Hippel-lindau Syndrome 1 100.00 Very High Very High Very High
Renal Cancer 15 99.88 Very High Very High Very High
Disease 14 94.96 High High
Metastasis 111 81.84 Quite High
Death 4 75.56 Quite High
Apoptosis 1 68.36 Quite High
Aggression 1 48.24 Quite Low
Disease Progression 8 5.00 Very Low Very Low Very Low
Recurrence 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In RCC, the loss of function of the Von Hippel Lindau (VHL) tumor supressor gene mediates up-regulation of CXCR4 [29] which then promotes tumor spread and progression [28].
Negative_regulation (loss) of VHL Positive_regulation (mediates) of Positive_regulation (regulation) of CXCR4 associated with cancer, von hippel-lindau syndrome and renal cancer
1) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2942853 Disease Relevance 1.64 Pain Relevance 0.05

General Comments

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