INT332832

Context Info Confidence 0.66 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 12 Disease Relevance 3.18 Pain Relevance 1.29

extracellular region (Fgf21)

Anatomy Link Frequency liver 2 acinar cells 2 fibroblast 2 Fgf21 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 19 99.62 Bile 176 98.84 Pain 11 34.52 cytokine 11 13.84 Eae 12 5.00 Spinal cord 11 5.00 sodium channel 11 5.00 Central nervous system 1 5.00 Inflammation 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Obesity 190 99.60 Targeted Disruption 408 99.58 Pancreatitis 11 97.68 Injury 11 96.60 Fatty Liver 55 85.20 Disease 73 77.08 Starvation 22 64.16 Weight Gain 12 59.64 Gallstones 11 53.96 Hypertrophy 11 46.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of Fgf21 was also induced in the liver by a high-fat, low-carbohydrate ketogenic diet.

Positive_regulation (induced) of Gene_expression (expression) of Fgf21 in liver

1) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.75 Pain Relevance 0

Fgf21 expression was markedly increased in mouse pancreatic acinar cells during cerulein-induced pancreatitis and following injury in vitro.

Positive_regulation (increased) of Gene_expression (expression) of Fgf21 in acinar cells associated with injury and pancreatitis

2) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.68 Pain Relevance 0

(Fgf21) Hepatic Fgf21 expression is induced by the activation of PPAR?.

Positive_regulation (induced) of Gene_expression (expression) of Fgf21

3) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.22

forms a heterodimer with RXRs and induces the expression of Fgf21.

Positive_regulation (induces) of Gene_expression (expression) of Fgf21

4) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.20

Klotho knockout mice indicates that Fgf21 signals are transduced in the absence of ?

Positive_regulation (transduced) of Gene_expression (signals) of Fgf21 associated with targeted disruption

5) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.62 Pain Relevance 0.07

Later, Fgf19, Fgf21, and Fgf23 were generated from Fgf19-like by two large-scale genome duplication events (Itoh and Ornitz 2004; Itoh and Ornitz 2008).

Positive_regulation (generated) of Gene_expression (generated) of Fgf21

6) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0

Hepatic Fgf21 expression during fasting might be induced through the activation of PPAR?

Positive_regulation (induced) of Gene_expression (expression) of Fgf21

7) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.18 Pain Relevance 0.17

Hepatic Fgf21 expression is greatly induced in wild-type mice but not PPAR?

Positive_regulation (induced) of Gene_expression (expression) of Fgf21

8) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.29 Pain Relevance 0.21

However, although hepatic Fgf21 expression is greatly induced in wild-type mice by fasting for 24 h, serum NEFA levels are essentially unchanged (Badman et al. 2007; Hotta et al. 2009).

Positive_regulation (induced) of Gene_expression (expression) of Fgf21

9) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.13

Later, Fgf15/19, Fgf21, and Fgf23 were generated from the ancestral gene by genome duplication events.

Positive_regulation (generated) of Gene_expression (generated) of Fgf21

10) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.08 Pain Relevance 0

(Fgf21) Hepatic Fgf21 expression is induced by the activation of PPAR?.

Positive_regulation (induced) of Gene_expression (expression) of Fgf21

11) Confidence 0.41 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.22

-agonist bezafibrate could induce circadian expression of fibroblast growth factor 21 (FGF21) [34], a hormone involved in lipolysis and hepatic ketogenesis [45], suggesting that bezafibrate-induced circadian effect is strictly PPAR?

Positive_regulation (induce) of Gene_expression (expression) of FGF21 in fibroblast associated with agonist

12) Confidence 0.38 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.05

General Comments

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