INT332832

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 3.18
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgf21)
Anatomy Link Frequency
liver 2
acinar cells 2
fibroblast 2
Fgf21 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 19 99.62 Very High Very High Very High
Bile 176 98.84 Very High Very High Very High
Pain 11 34.52 Quite Low
cytokine 11 13.84 Low Low
Eae 12 5.00 Very Low Very Low Very Low
Spinal cord 11 5.00 Very Low Very Low Very Low
sodium channel 11 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 190 99.60 Very High Very High Very High
Targeted Disruption 408 99.58 Very High Very High Very High
Pancreatitis 11 97.68 Very High Very High Very High
Injury 11 96.60 Very High Very High Very High
Fatty Liver 55 85.20 High High
Disease 73 77.08 Quite High
Starvation 22 64.16 Quite High
Weight Gain 12 59.64 Quite High
Gallstones 11 53.96 Quite High
Hypertrophy 11 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Fgf21 was also induced in the liver by a high-fat, low-carbohydrate ketogenic diet.
Positive_regulation (induced) of Gene_expression (expression) of Fgf21 in liver
1) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.75 Pain Relevance 0
Fgf21 expression was markedly increased in mouse pancreatic acinar cells during cerulein-induced pancreatitis and following injury in vitro.
Positive_regulation (increased) of Gene_expression (expression) of Fgf21 in acinar cells associated with injury and pancreatitis
2) Confidence 0.66 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.68 Pain Relevance 0
(Fgf21) Hepatic Fgf21 expression is induced by the activation of PPAR?.
Positive_regulation (induced) of Gene_expression (expression) of Fgf21
3) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.22
forms a heterodimer with RXRs and induces the expression of Fgf21.
Positive_regulation (induces) of Gene_expression (expression) of Fgf21
4) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.20
Klotho knockout mice indicates that Fgf21 signals are transduced in the absence of ?
Positive_regulation (transduced) of Gene_expression (signals) of Fgf21 associated with targeted disruption
5) Confidence 0.48 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.62 Pain Relevance 0.07
Later, Fgf19, Fgf21, and Fgf23 were generated from Fgf19-like by two large-scale genome duplication events (Itoh and Ornitz 2004; Itoh and Ornitz 2008).
Positive_regulation (generated) of Gene_expression (generated) of Fgf21
6) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0 Pain Relevance 0
Hepatic Fgf21 expression during fasting might be induced through the activation of PPAR?
Positive_regulation (induced) of Gene_expression (expression) of Fgf21
7) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.18 Pain Relevance 0.17
Hepatic Fgf21 expression is greatly induced in wild-type mice but not PPAR?
Positive_regulation (induced) of Gene_expression (expression) of Fgf21
8) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.29 Pain Relevance 0.21
However, although hepatic Fgf21 expression is greatly induced in wild-type mice by fasting for 24 h, serum NEFA levels are essentially unchanged (Badman et al. 2007; Hotta et al. 2009).
Positive_regulation (induced) of Gene_expression (expression) of Fgf21
9) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0.13
Later, Fgf15/19, Fgf21, and Fgf23 were generated from the ancestral gene by genome duplication events.
Positive_regulation (generated) of Gene_expression (generated) of Fgf21
10) Confidence 0.44 Published 2010 Journal Cell Tissue Res Section Abstract Doc Link PMC2948652 Disease Relevance 0.08 Pain Relevance 0
(Fgf21) Hepatic Fgf21 expression is induced by the activation of PPAR?.
Positive_regulation (induced) of Gene_expression (expression) of Fgf21
11) Confidence 0.41 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.13 Pain Relevance 0.22
-agonist bezafibrate could induce circadian expression of fibroblast growth factor 21 (FGF21) [34], a hormone involved in lipolysis and hepatic ketogenesis [45], suggesting that bezafibrate-induced circadian effect is strictly PPAR?
Positive_regulation (induce) of Gene_expression (expression) of FGF21 in fibroblast associated with agonist
12) Confidence 0.38 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.05

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