INT332896

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hdac3, Ncor1) DNA binding (Hdac3, Ncor1) cytoplasm (Hdac3, Ncor1)
Hdac3 (Mus musculus)
Ncor1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 48 46.60 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 100.00 Very High Very High Very High
Metabolic Syndrome 48 99.00 Very High Very High Very High
Body Weight 6 94.52 High High
Thinness 12 93.60 High High
Repression 18 90.32 High High
Disease 42 5.00 Very Low Very Low Very Low
Stress 24 5.00 Very Low Very Low Very Low
Sleep Disorders 18 5.00 Very Low Very Low Very Low
Obesity 18 5.00 Very Low Very Low Very Low
Hypertension 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In NcoR1 mutant knock-in mice, uncoupling of NcoR1 from binding to Hdac3 led to altered circadian rhythmicity [39].
Hdac3 Binding (binding) of NcoR1 associated with targeted disruption
1) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.18 Pain Relevance 0
Thus, uncoupling NcoR1/Hdac3 interaction could be beneficial for metabolic syndrome management.

2.3.2.

Hdac3 Binding (interaction) of NcoR1 associated with metabolic syndrome
2) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.38 Pain Relevance 0
Thus, uncoupling NcoR1/Hdac3 interaction could be beneficial for metabolic syndrome management.

2.3.2.

Hdac3 Binding (interaction) of NcoR1 associated with metabolic syndrome
3) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.38 Pain Relevance 0
A mouse line was generated to harbor a mutation in NcoR1 DAD domain that abolished the ability of NcoR1 to interact with or activate Hdac3 [39].
Hdac3 Binding (interact) of NcoR1
4) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.18 Pain Relevance 0
In NcoR1 mutant knock-in mice, uncoupling of NcoR1 from binding to Hdac3 led to altered circadian rhythmicity [39].
Hdac3 Binding (binding) of NcoR1 associated with targeted disruption
5) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.18 Pain Relevance 0
Histone deacetylase 3 (Hdac3), a histone modification enzyme, is recruited and stably bound to the repressor complex through a conserved deacetylase activation domain (DAD) in NcoR1 [39].
Hdac3 Binding (bound) of NcoR1
6) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox