INT3329

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Context Info
Confidence 1.00
First Reported 1978
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.95
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 2
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 3 98.36 Very High Very High Very High
beta blocker 7 75.52 Quite High
anesthesia 4 25.00 Low Low
action potential duration 13 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 3 98.36 Very High Very High Very High
Arrhythmias 2 Under Development 8 96.80 Very High Very High Very High
Myocardial Infarction 62 95.12 Very High Very High Very High
Pressure And Volume Under Development 14 58.08 Quite High
Cough 1 57.52 Quite High
Natriuresis 4 53.36 Quite High
Hypertension 6 34.80 Quite Low
Death 13 23.76 Low Low
Body Weight 1 7.28 Low Low
Renal Disease 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The incubation of 125I-rh-renin with monkey or human plasma at 37 degrees C did not degrade the labeled renin.
Neg (not) Protein_catabolism (degrade) of renin in plasma
1) Confidence 1.00 Published 1988 Journal Hypertension Section Abstract Doc Link 3049339 Disease Relevance 0 Pain Relevance 0
The incubation of 125I-rh-renin with monkey or human plasma at 37 degrees C did not degrade the labeled renin.
Neg (not) Protein_catabolism (degrade) of 125I-rh-renin in plasma
2) Confidence 0.77 Published 1988 Journal Hypertension Section Abstract Doc Link 3049339 Disease Relevance 0 Pain Relevance 0
This may be due to the very high degree of renin┬ľangiotensin system activation in these patients, requiring a dual blockade to be fully reversed.
Protein_catabolism (degree) of renin
3) Confidence 0.74 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.61 Pain Relevance 0.07
In excess, the magnitude of which varies among individuals, trypsin at first produces activation and later a decline in PRA, probably due to degradation of the reactants (prorenin, renin, angiotensinogen) and of the initial product (angiotensin I).
Protein_catabolism (degradation) of renin
4) Confidence 0.64 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 709420 Disease Relevance 0 Pain Relevance 0
As Cx (NEPI) also inhibits the degradation of active-renin or Ang II, it may show an inverse effect on preventing the construction of the atrial fibrillation substrate.
Protein_catabolism (degradation) of active-renin associated with arrhythmias 2 under development
5) Confidence 0.09 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2267894 Disease Relevance 0.34 Pain Relevance 0.05

General Comments

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