INT332953

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lepr) extracellular space (Lepr) extracellular region (Lepr)
plasma membrane (Lepr)
Anatomy Link Frequency
body 4
Lepr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 142 99.82 Very High Very High Very High
Obesity 266 97.94 Very High Very High Very High
Weight Gain 8 85.60 High High
Disorder Of Lipid Metabolism 24 5.00 Very Low Very Low Very Low
Metabolic Disorder 18 5.00 Very Low Very Low Very Low
Cardiovascular Disease 16 5.00 Very Low Very Low Very Low
Diabetes Mellitus 16 5.00 Very Low Very Low Very Low
Insulin Resistance 10 5.00 Very Low Very Low Very Low
Dyslipidemia /

Combined Dyslipidemia

10 5.00 Very Low Very Low Very Low
Hypertrophy 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fenofibrate seems to differentially affect body weight and adiposity among OVX and Sham mice by a mechanism other than the modulation of leptin gene expression.
Regulation (modulation) of Gene_expression (expression) of leptin gene in body associated with body weight
1) Confidence 0.52 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.41 Pain Relevance 0
Consistent with this finding, Guerre-Millo et al. [10] reported that serum leptin concentrations positively correlated with body weight and epididymal adipose tissue mass in fenofibrate-treated male mice [10], suggesting that fenofibrate modulates body weight, not by influencing leptin gene expression and food intake, but by enhancing energy expenditure [91, 92].
Regulation (influencing) of Gene_expression (expression) of leptin gene in body associated with body weight and obesity
2) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.02 Pain Relevance 0

General Comments

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