INT332984

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Ads1 (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 2 74.76 Quite High
methotrexate 1 74.08 Quite High
rheumatoid arthritis 8 63.60 Quite High
cytokine 16 17.04 Low Low
Pain 1 11.92 Low Low
abatacept 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 4 99.90 Very High Very High Very High
Infection 13 98.44 Very High Very High Very High
Renal Disease 24 97.56 Very High Very High Very High
Disease 43 94.88 High High
Systemic Lupus Erythematosus 137 92.72 High High
Diabetes Mellitus 1 86.24 High High
Hirsutism 1 83.48 Quite High
Gingival Hypertrophy 1 82.76 Quite High
General Immunology 1 81.84 Quite High
Nephrotoxicity 1 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tacrolimus was more effective in improving proteinuria and inhibiting anti-dsDNA antibody production with a reduced incidence of pulmonary infections.35 Another small study with a total of 60 patients showed comparable efficacy of MMF, tacrolimus, and intravenous cyclophosphamide in lupus nephritis regarding complete remission.36 Phase III trials with tacrolimus or a combination of tacrolimus and MMF have already been completed or are recruiting (www.ClinicalTrials.gov) and results should be available soon.


Negative_regulation (inhibiting) of Gene_expression (production) of anti-dsDNA antibody associated with renal disease, proteinuria and infection
1) Confidence 0.42 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 1.06 Pain Relevance 0
Idiotypic vaccines developed anti-DNA antibody vaccines in mice.
Negative_regulation (developed) of Gene_expression (vaccines) of anti-DNA antibody
2) Confidence 0.02 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.84 Pain Relevance 0.11

General Comments

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