INT33299

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Context Info
Confidence 0.31
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.88
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR7) intracellular (CCR7) signal transducer activity (CCR7)
Anatomy Link Frequency
CD86 2
CCR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 143 99.60 Very High Very High Very High
Morphine 1 97.12 Very High Very High Very High
Enkephalin 2 95.04 Very High Very High Very High
chemokine 73 93.08 High High
agonist 7 92.40 High High
opiate 2 88.96 High High
cytokine 12 61.92 Quite High
Inflammation 46 59.76 Quite High
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 143 99.60 Very High Very High Very High
Infection 97 99.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 45 97.68 Very High Very High Very High
Immunodeficiency 5 93.20 High High
Adenocarcinoma 90 90.48 High High
Cancer 35 87.00 High High
Neuroblastoma 3 84.80 Quite High
Disease Progression 14 66.00 Quite High
Disease 36 60.92 Quite High
INFLAMMATION 48 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the same receptors could be observed on the non-RA membranes with the exception of Bob, CCR7 and CCR9.
CCR7 Neg (exception) Binding (exception) of associated with rheumatoid arthritis
1) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.18 Pain Relevance 0.88
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
CCR7 Spec (clear) Binding (levels) of in CD86
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03
A majority of CCR7+ mDC in progressor animals also expressed CD86 with a smaller proportion expressing CD80, consistent with activation (Figure 3E).
CCR7 Binding (majority) of in CD86
3) Confidence 0.18 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.84 Pain Relevance 0.05
Dextrorphan and the mu specific peptide morphiceptin (Tyr-Pro-Phe-Pro-CO-NH2) do not bind to the site.
mu specific peptide morphiceptin Neg (not) Binding (bind) of
4) Confidence 0.03 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3000378 Disease Relevance 0.25 Pain Relevance 0.50

General Comments

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