INT3330

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Context Info
Confidence 0.76
First Reported 1978
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 149
Total Number 152
Disease Relevance 98.65
Pain Relevance 22.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
blood 12
plasma 8
heart 5
ciliary bodies 3
smooth muscle cells 3
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 202 100.00 Very High Very High Very High
bradykinin 197 100.00 Very High Very High Very High
Enkephalin 116 100.00 Very High Very High Very High
beta blocker 106 100.00 Very High Very High Very High
Catecholamine 30 100.00 Very High Very High Very High
Serotonin 26 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
Inflammation 675 99.96 Very High Very High Very High
Cholecystokinin 6 99.92 Very High Very High Very High
chemokine 55 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 903 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 775 100.00 Very High Very High Very High
Pressure And Volume Under Development 615 100.00 Very High Very High Very High
Insulin Resistance 167 100.00 Very High Very High Very High
Natriuresis 104 100.00 Very High Very High Very High
Amyloidosis 18 100.00 Very High Very High Very High
INFLAMMATION 785 99.96 Very High Very High Very High
Targeted Disruption 98 99.88 Very High Very High Very High
Atherosclerosis 297 99.84 Very High Very High Very High
Diabetic Retinopathy 252 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of angiotensin II and III in FF in increasing concentrations depending on the maturity of the follicle and the inability of general anesthesia to affect the AII/III concentrations suggests that this peptide is produced within the ovary.
Gene_expression (presence) of angiotensin II in follicle associated with anesthesia
1) Confidence 0.76 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2459891 Disease Relevance 0 Pain Relevance 0.56
As we were not able to measure plasma levels of renin, angiotensin and vasopressin, interactions between these three hormones in this particular situation cannot be excluded.
Gene_expression (levels) of angiotensin in plasma
2) Confidence 0.75 Published 1998 Journal Crit Care Section Body Doc Link PMC29001 Disease Relevance 0.17 Pain Relevance 0.03
Studies employing mice in which genes involved in angiotensin generation and encoding AngII receptors have been disrupted have provided information about the functions of these genes.
Gene_expression (generation) of angiotensin
3) Confidence 0.75 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.59 Pain Relevance 0
Further studies have indicated an intrarenal role of RAAS by detecting the
               angiotensinogen, angiotensin-converting enzyme (ACE), angiotensin II type 1 (AT1)
               receptor, and angiotensin II within cysts and tubules of ADPKD kidneys (Loghman-Adham et al 2004). 
Gene_expression (detecting) of angiotensinogen in tubules associated with autosomal dominant polycystic kidney and cyst
4) Confidence 0.75 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504069 Disease Relevance 1.66 Pain Relevance 0.08
and components of the renin-angiotensin system (RAS) are expressed in the
Gene_expression (expressed) of angiotensin
5) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.85 Pain Relevance 0.17
The rat and human renin-angiotensin systems do not interact, so the hypertension and vasculopathy exhibited by these rats is the result of the overexpression of the human renin-angiotensin system.
Gene_expression (overexpression) of angiotensin associated with hypertension
6) Confidence 0.75 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.92 Pain Relevance 0.20
It remains to be demonstrated whether angiotensin II acting in brain to modulate activity of opioid neurons is synthesized in brain or is derived peripherally.
Gene_expression (synthesized) of angiotensin II in brain associated with opioid
7) Confidence 0.74 Published 1983 Journal Peptides Section Abstract Doc Link 6306616 Disease Relevance 0 Pain Relevance 0.48
Over the last two decades, a growing number of experimental and clinical studies provided evidence of an important role played by angiotensin II along the different steps of the cardiovascular disease continuum.5 It is well known that angiotensin II is produced through the aminoacid cleavage of angiotensin I operated by the angiotensin-converting enzyme (ACE) in some tissues including the lung, as well as in the myocardium, through the effects of specific proteases on angiotensin I.
Gene_expression (produced) of angiotensin II in myocardium associated with cardiovascular disease
8) Confidence 0.71 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 1.14 Pain Relevance 0
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Gene_expression (production) of angiotensin II in heart associated with heart rate under development
9) Confidence 0.71 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.98 Pain Relevance 0.13
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Gene_expression (production) of angiotensin II in heart associated with heart rate under development
10) Confidence 0.71 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.83 Pain Relevance 0.12
A six point concentration: response curved of the contractile effect of angiotensin II (AII) on helically-cut strips of human chorionic plate artery strips were established at final concentrations of between 10(-14) to 10(-9) M.
Gene_expression (effect) of angiotensin II in artery
11) Confidence 0.68 Published 1989 Journal West Afr J Med Section Abstract Doc Link 2486765 Disease Relevance 0.21 Pain Relevance 0.15
The same stimulus also triggers an increase in the levels of circulating vasoactive hormones, such as norepinephrine and angiotensin II, further augmenting arteriolar tone.
Gene_expression (levels) of angiotensin II
12) Confidence 0.66 Published 1993 Journal Physiologist Section Abstract Doc Link 11537414 Disease Relevance 0.56 Pain Relevance 0.06
[Use of isosorbide dinitrate and antagonists of angiotensin II in patients with stable angina pectoris in early stages of cardiac insufficiency].
Gene_expression (antagonists) of angiotensin II associated with stable angina pectoris, heart rate under development, angina and antagonist
13) Confidence 0.66 Published 2001 Journal Lik. Sprava Section Title Doc Link 11519419 Disease Relevance 0.38 Pain Relevance 0.29
It has previously been shown that BP responses to stimuli such as aerobic exercise, mental stress, and other laboratory tests are greater in hypertensive subjects than in normotensive subjects.14, 15 This greater responsiveness might be linked to the fact that hypertensive patients, in addition to presenting greater sympathetic activity at rest,30 also present greater sympathetic activation during stress and greater hemodynamic responsiveness to sympathetic activation,15 Other mechanisms, such as the renin-angiotensin system, are also enhanced in hypertension and might therefore increase BP responsiveness.31
Gene_expression (system) of angiotensin in sympathetic associated with stress and hypertension
14) Confidence 0.65 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845767 Disease Relevance 1.01 Pain Relevance 0
The mechanism of angioedema in patients taking ACEIs involves the inhibition of ACE, which blocks the conversion of angiotensin, reduces the catabolism of bradykinin, and increases its activity.10 Decreased aminopeptidase P (APP) activity and dipeptidyl peptidase P in the substance P degradation pathways also seem to play a role.11 Furthermore, a polymorphism of XPNPEP2 (the -2399 A variant), a candidate gene encoding membrane-bound APP, is associated with reduced APP activity and a higher incidence of ACEI-induced angioedema.12
Gene_expression (conversion) of angiotensin associated with pressure and volume under development, bradykinin and substance p
15) Confidence 0.65 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892052 Disease Relevance 1.20 Pain Relevance 0.47
Hypertension is common among diabetics and has the same pathogenetic mechanisms as insulin resistance, in which the activated renin–angiotensin system contributes to the increased high blood pressure and hyperglycemia.
Gene_expression (resistance) of angiotensin in blood associated with hyperglycemia, diabetes mellitus, hypertension and insulin resistance
16) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901187 Disease Relevance 2.05 Pain Relevance 0.10
Blockade of the renin-angiotensin system plus calcium entry blockade or diuretic therapy
Gene_expression (system) of angiotensin
17) Confidence 0.65 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2672450 Disease Relevance 0.20 Pain Relevance 0
Angiotensin IV is a component of the renin-angiotensin system, a metabolic product of the potent vasoconstrictor angiotensin II (Figures 1 and 2).
Gene_expression (product) of angiotensin
18) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.37 Pain Relevance 0.03
There is increasing evidence that certain vasoactive substances such as vascular endothelial growth factor (VEGF), cytokines (IL-2, IL-6, and IL-8), tumor necrosis factor-alpha (TNF-alpha), and the ovarian renin-angiotensin system, which are activated by gonadotropin, can lead to increased vascular permeability and extravascular fluid accumulation in OHSS [6,7].
Gene_expression (system) of angiotensin associated with ovarian hyperstimulation syndrome, necrosis, cancer, edema and cytokine
19) Confidence 0.65 Published 2008 Journal Cases J Section Body Doc Link PMC2596110 Disease Relevance 1.48 Pain Relevance 0.08
The rat and human renin-angiotensin systems do not interact, so the hypertension and vasculopathy exhibited by these rats is the result of the overexpression of the human renin-angiotensin system.
Gene_expression (systems) of angiotensin associated with hypertension
20) Confidence 0.65 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.75 Pain Relevance 0.16

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