INT333015

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.43
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv4) plasma membrane (Trpv4) cilium (Trpv4)
transmembrane transport (Trpv4)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 93.12 High High
TRP channel 28 85.64 High High
Catecholamine 4 75.32 Quite High
potassium channel 4 8.28 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Channelopathies 4 97.32 Very High Very High Very High
Stress 16 75.60 Quite High
Apoptosis 12 69.16 Quite High
Myocardial Infarction 4 61.64 Quite High
Disease 4 42.56 Quite Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low
Hypesthesia 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So what purpose does this constitutive interaction of AT1aR and TRPV4, or any other 7TMR with an ion channel, serve?
Regulation (serve) of TRPV4 Binding (interaction) of
1) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Thus, to confirm the specificity of interaction of TRPV4 with ?
Regulation (specificity) of TRPV4 Binding (interaction) of
2) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin interaction with TRPV4 and describe a novel regulatory mechanism governing the functional down-regulation of TRPV4.
Regulation (regulation) of TRPV4 Binding (interaction) of
3) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0.43 Pain Relevance 0.08
In yet another approach to confirm internalization of TRPV4 and to investigate whether internalization of TRPV4 translates into a functional down-regulation, we measured 4-?
Spec (whether) Regulation (regulation) of TRPV4 Spec (whether) Binding (internalization) of
4) Confidence 0.42 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.05

General Comments

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