INT333030

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Itch, Trpv4) transport (Trpv4) intracellular (Itch)
cilium (Trpv4) transmembrane transport (Trpv4) ligase activity (Itch)
Itch (Mus musculus)
Trpv4 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 35 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
potassium channel 5 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Neuropathic pain 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Catecholamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 15 5.00 Very Low Very Low Very Low
Coronary Heart Disease 5 5.00 Very Low Very Low Very Low
Hypesthesia 5 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Channelopathies 5 5.00 Very Low Very Low Very Low
Myocardial Infarction 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, TRPV4 does not contain a consensus PY motif, and therefore, it was proposed that an adaptor protein may facilitate the recruitment of AIP4 to TRPV4.
AIP4 Binding (recruitment) of TRPV4
1) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
AIP4 (atrophin 1-interacting protein 4), a member of the HECT (homologous to E6-AP carboxyl terminus) family of ubiquitin ligases, was recently identified as the relevant ligase for TRPV4 ubiquitination (42).
AIP4 Binding (ligase) of TRPV4
2) Confidence 0.14 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Interestingly, this interaction between TRPV4 and AIP4 was dependent on the presence of ?
AIP4 Binding (interaction) of TRPV4
3) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 4, C and D, angiotensin stimulation promoted a significant interaction between TRPV4 and AIP4.
AIP4 Binding (interaction) of TRPV4
4) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
-arrestin 1 acts as an adaptor for AIP4, we examined the interaction between TRPV4 and AIP4 in response to angiotensin stimulation.
AIP4 Spec (examined) Binding (interaction) of TRPV4
5) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0

General Comments

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