INT333037

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.03

transport (Trpv4) extracellular space (Agt) plasma membrane (Trpv4) cilium (Trpv4) extracellular matrix organization (Agt) transmembrane transport (Trpv4)

Agt (Mus musculus) Trpv4 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 6 67.68 TRP channel 14 5.00 potassium channel 2 5.00 Central nervous system 2 5.00 Neuropathic pain 2 5.00 Peripheral nervous system 2 5.00 Inflammation 2 5.00 Catecholamine 2 5.00

Disease Link Frequency Relevance Heat Stress 8 5.00 Apoptosis 6 5.00 Increased Venous Pressure Under Development 6 5.00 Coronary Heart Disease 2 5.00 Hypesthesia 2 5.00 Disease 2 5.00 Neuropathic Pain 2 5.00 INFLAMMATION 2 5.00 Channelopathies 2 5.00 Myocardial Infarction 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To further confirm this finding, we used a surface biotinylation assay to get a quantitative assessment of angiotensin-induced internalization of TRPV4.

angiotensin-induced Binding (internalization) of TRPV4

1) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.03

As shown in Fig. 1, A and B, angiotensin stimulation led to a robust but transient interaction between TRPV4 and ?

angiotensin Binding (interaction) of TRPV4

2) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0

General Comments

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