INT33308

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Context Info
Confidence 0.15
First Reported 1985
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.44
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ap1m2) vesicle-mediated transport (Ap1m2) Golgi apparatus (Ap1m2)
Anatomy Link Frequency
brain 1
central nervous system 1
Ap1m2 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 13 100.00 Very High Very High Very High
Enkephalin 10 100.00 Very High Very High Very High
Intracerebroventricular 1 100.00 Very High Very High Very High
Opioid 18 99.96 Very High Very High Very High
opioid receptor 8 99.92 Very High Very High Very High
Central nervous system 6 98.84 Very High Very High Very High
opiate 6 94.00 High High
antagonist 2 92.44 High High
Analgesic 3 91.44 High High
tail-flick 1 83.60 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 80.88 Quite High
Pain 3 64.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used [3H]dihydromorphine (DHM) to visualize total mu sites (mu1 and mu2) and [3H]DHM plus a low concentration of [D-Ala2-D-Leu5]enkephalin (DADL) to visualize mu2 sites.
Gene_expression (visualize) of mu2 associated with enkephalin
1) Confidence 0.15 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.22 Pain Relevance 1.22
We have used quantitative in vitro autoradiography to compare the levels of mu1 and mu2 opioid binding in the mouse central nervous system.
Gene_expression (levels) of mu2 in central nervous system associated with central nervous system and opioid
2) Confidence 0.13 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0 Pain Relevance 0.74
We used [3H]dihydromorphine (DHM) to visualize total mu sites (mu1 and mu2) and [3H]DHM plus a low concentration of [D-Ala2-D-Leu5]enkephalin (DADL) to visualize mu2 sites.
Gene_expression (visualize) of mu2 associated with enkephalin
3) Confidence 0.13 Published 1985 Journal Brain Res. Section Abstract Doc Link 3000529 Disease Relevance 0.22 Pain Relevance 1.20
The purpose of the present study was to determine if the highly mu-selective compound etonitazene could produce supraspinal (intracerebroventricular; i.c.v.) antinociception in CXBK mice, which are deficient in brain mu1, but not mu2, opioid receptors.
Gene_expression (produce) of mu2 in brain associated with antinociception, opioid receptor and intracerebroventricular
4) Confidence 0.04 Published 1994 Journal Life Sci. Section Abstract Doc Link 7910928 Disease Relevance 0 Pain Relevance 1.07
The results indicate that endomorphins may produce antinociception through the distinct mu1 and mu2 subtypes of mu-opioid receptor.
Gene_expression (produce) of mu2 associated with antinociception and opioid receptor
5) Confidence 0.01 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374711 Disease Relevance 0 Pain Relevance 0.85

General Comments

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