INT333086

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 12.29
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HNRNPA1) transport (HNRNPA1) mRNA processing (HNRNPA1)
nucleolus (HNRNPA1) RNA binding (HNRNPA1) nucleus (HNRNPA1)
Anatomy Link Frequency
neurons 4
astrocytes 4
neuronal 2
HNRNPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 99.68 Very High Very High Very High
cytokine 88 99.16 Very High Very High Very High
chemokine 56 87.28 High High
Neurobehavioral 56 87.20 High High
Inflammatory response 16 32.88 Quite Low
Central nervous system 24 5.00 Very Low Very Low Very Low
glial activation 16 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 1512 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 96 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 584 99.84 Very High Very High Very High
INFLAMMATION 48 99.68 Very High Very High Very High
Infection 272 99.66 Very High Very High Very High
Injury 88 99.48 Very High Very High Very High
Death 40 97.28 Very High Very High Very High
Targeted Disruption 96 96.64 Very High Very High Very High
Cancer 24 94.00 High High
Necrosis 24 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HIV-1 infection and Vpr protein potentiate the neuroimmune activation and neurotoxic effects of HCV core protein
Positive_regulation (potentiate) of Gene_expression (effects) of core protein associated with acquired immune deficiency syndrome or hiv infection, hepatitis c virus infection and infection
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.97 Pain Relevance 0.13
To determine if HCV core protein exerted its neurotoxic effects indirectly through induction of neurotoxic factors secreted by microglia or astrocytes, supernatants from HFAs or HFµ?
Positive_regulation (exerted) of Gene_expression (exerted) of core protein in astrocytes associated with hepatitis c virus infection
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.14 Pain Relevance 0.03
Direct or indirect exposure of HCV core protein results in neuronal injury
Positive_regulation (results) of Gene_expression (exposure) of core protein in neuronal associated with injury and hepatitis c virus infection
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.06 Pain Relevance 0.12
HCV core protein exposure induced expression of pro-inflammatory cytokines including interleukin-1?
Positive_regulation (induced) of Gene_expression (expression) of core protein associated with inflammation, hepatitis c virus infection and cytokine
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.52 Pain Relevance 0.19
To determine if HCV core protein exerted its neurotoxic effects indirectly through induction of neurotoxic factors secreted by microglia or astrocytes, supernatants from HFAs or HFµ?
Positive_regulation (induction) of Gene_expression (exerted) of core protein in astrocytes associated with hepatitis c virus infection
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.17 Pain Relevance 0.03
HCV core protein exposure was not toxic to astrocytes (Figure 4A) while the highest concentration of HCV core protein (100 nM) was cytotoxic to neurons, indicated by the loss of ?
Positive_regulation (HCV) of Gene_expression (exposure) of core protein in neurons associated with hepatitis c virus infection
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.01 Pain Relevance 0.06
HCV core protein neurotoxicity and interleukin-6 induction were potentiated by HIV-1 Vpr protein (p<0.05).
Positive_regulation (potentiated) of Gene_expression (neurotoxicity) of core protein associated with drug induced neurotoxicity, acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.40 Pain Relevance 0.20
HCV core protein exposure was not toxic to astrocytes (Figure 4A) while the highest concentration of HCV core protein (100 nM) was cytotoxic to neurons, indicated by the loss of ?
Neg (not) Positive_regulation (toxic) of Gene_expression (exposure) of core protein in neurons associated with hepatitis c virus infection
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.01 Pain Relevance 0.06

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