INT333209

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.54
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr7) plasma membrane (Cxcr7) signal transducer activity (Cxcr7)
Anatomy Link Frequency
MCF7 1
Cxcr7 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 93 99.96 Very High Very High Very High
Hippocampus 35 50.68 Quite High
imagery 16 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 100 99.74 Very High Very High Very High
Breast Cancer 16 99.44 Very High Very High Very High
Adhesions 140 96.64 Very High Very High Very High
Carcinoma 100 94.04 High High
Apoptosis 185 88.92 High High
Bordatella Infection 12 72.60 Quite High
Metastasis 100 71.28 Quite High
Repression 20 55.52 Quite High
Convulsion 44 26.48 Quite Low
Cancer 72 24.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate CXCL12-mediated guidance mechanisms, we next examined expression of CXCR4 and CXCR7, the two receptors that bind CXCL12 [39].
Spec (examined) Gene_expression (expression) of CXCR7
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.11
CXCL12, CXCR4 and CXCR7 expression were amplified using 33 cycles of 94°C for 30 sec, 60°C for 30 sec, and 72°C for 30 sec.
Gene_expression (expression) of CXCR7
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.13 Pain Relevance 0
Rabbit polyclonal antibody was used to detect CXCR7 (Abcam, Cambridge, MA, USA).
Gene_expression (detect) of CXCR7
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0 Pain Relevance 0
Initial characterization of HT29 and HCT116 human colorectal carcinoma cells shows expression of both CXCR4 and CXCR7 chemokine receptors with no detectable CXCL12 expression.
Gene_expression (expression) of CXCR7 associated with chemokine and colon cancer
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.27 Pain Relevance 0.05
MCF7 breast cancer cells, previously shown to express CXCR7 and CXCL12, were used as a positive control (Figure 1A) [23], [26].
Gene_expression (express) of CXCR7 in MCF7 associated with breast cancer
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.14 Pain Relevance 0.05

General Comments

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