INT333232

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.35
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
brains 2
hippocampus 2
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 61 100.00 Very High Very High Very High
Hippocampus 35 99.68 Very High Very High Very High
cytokine 30 89.76 High High
Inflammation 12 81.88 Quite High
imagery 8 49.44 Quite Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 44 99.98 Very High Very High Very High
Cancer 38 99.96 Very High Very High Very High
Disease 69 99.60 Very High Very High Very High
Colon Cancer 50 98.72 Very High Very High Very High
Carcinoma 50 92.36 High High
Breast Cancer 8 89.36 High High
INFLAMMATION 12 81.88 Quite High
Immunization 47 77.28 Quite High
Hyperplasia 2 74.64 Quite High
Apoptosis 93 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next asked whether seizures impacted the expression of CXCL12 in the hippocampus.
Spec (whether) Negative_regulation (impacted) of Gene_expression (expression) of CXCL12 in hippocampus associated with convulsion and hippocampus
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.50 Pain Relevance 0.13
Herein, we show re-establishment of CXCL12 expression is a novel inducer of Bim and Bak in colorectal carcinoma cells and sensitizes these cells to anoikis.
Negative_regulation (establishment) of Gene_expression (expression) of CXCL12 associated with colon cancer
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.11 Pain Relevance 0.08
Together these data suggest that constitutive CXCL12 expression and production inhibits tumor formation by sensitizing colorectal carcinoma cells to anoikis via upregulation of the Bim regulator.


Negative_regulation (inhibits) of Gene_expression (expression) of CXCL12 associated with cancer and colon cancer
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.72 Pain Relevance 0.04
Expression of the chemokine SDF1 is decreased in early AD brains [32], suggesting that disregulation of its chemotactic signaling properties may either be an early symptom of AD or may contribute to later AD pathology.


Negative_regulation (decreased) of Gene_expression (Expression) of SDF1 in brains associated with chemokine and disease
4) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 1.02 Pain Relevance 0.32

General Comments

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