INT333239

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.48
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
epithelial cells 2
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 105 78.92 Quite High
imagery 20 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 230 99.78 Very High Very High Very High
Colon Cancer 125 99.44 Very High Very High Very High
Death 35 98.98 Very High Very High Very High
Adhesions 175 98.56 Very High Very High Very High
Cancer 90 97.60 Very High Very High Very High
Metastasis 125 95.44 Very High Very High Very High
Carcinoma 125 88.00 High High
Bordatella Infection 15 73.32 Quite High
Repression 25 8.96 Low Low
Breast Cancer 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL12, CXCR4 and CXCR7 expression were amplified using 33 cycles of 94°C for 30 sec, 60°C for 30 sec, and 72°C for 30 sec.
Regulation (amplified) of Gene_expression (expression) of CXCL12
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.14 Pain Relevance 0
Autocrine CXCL12 expression sensitizes epithelial cells to anoikis
Regulation (sensitizes) of Gene_expression (expression) of CXCL12 in epithelial cells
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.32 Pain Relevance 0.07
Together these data describe a role for tonic CXCL12 expression and production in regulating focal adhesion stability and cellular adherence.


Regulation (role) of Gene_expression (expression) of CXCL12 associated with adhesions
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.32 Pain Relevance 0.08
These results underscore the importance of retaining CXCL12 expression to sensitize colorectal carcinomas to anoikis and minimize tumor progression.



Regulation (importance) of Gene_expression (expression) of CXCL12 associated with cancer and colon cancer
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943927 Disease Relevance 1.11 Pain Relevance 0.04
As both intrinsic and extrinsic apoptotic mechanisms have been implicated in detachment-induced cell death [2], we next investigated the apoptotic mechanism regulating anoikis sensitivity in response to tonic CXCL12 production.
Spec (investigated) Regulation (regulating) of Gene_expression (production) of CXCL12 associated with apoptosis and death
5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.60 Pain Relevance 0

General Comments

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