INT333246

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.99
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cxcr4, Cxcl12) endosome (Cxcr4) extracellular space (Cxcl12)
signal transduction (Cxcr4) extracellular region (Cxcl12) cytoplasmic membrane-bounded vesicle (Cxcr4)
Anatomy Link Frequency
neurons 1
Cxcr4 (Mus musculus)
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 32 100.00 Very High Very High Very High
Hippocampus 35 66.20 Quite High
imagery 15 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 25 99.48 Very High Very High Very High
Apoptosis 47 96.04 Very High Very High Very High
Toxicity 1 84.80 Quite High
Death 11 74.44 Quite High
Obesity 13 71.12 Quite High
Cancer 18 69.20 Quite High
Carcinoma 25 66.72 Quite High
Metastasis 25 57.84 Quite High
Targeted Disruption 3 56.08 Quite High
Injury 36 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In culture, ESNPs, as well as ESC-derived immature neurons, expressed CXCR4, a receptor for CXCL12 required for CXCL12-mediated chemotaxis (Figure 3A, B).
CXCR4 Binding (receptor) of CXCL12 in neurons
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.17
CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes including cellular migration, survival, and apoptosis [14]–[16].
CXCR4 Binding (binds) of CXCL12 associated with apoptosis
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.78 Pain Relevance 0.05
AT-SCs have been shown to express the CXCR4 alpha-chemokine receptor specific for stromal-derived factor-1, and its overexpression increases AT-SCs migration and proliferation [40].
CXCR4 Binding (receptor) of stromal-derived factor-1 associated with chemokine
3) Confidence 0.19 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.21 Pain Relevance 0.05

General Comments

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