INT333253

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.14
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2, Mcl1) cytoplasm (Bcl2, Mcl1) nucleus (Bcl2, Mcl1)
cell differentiation (Mcl1) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
Bcl2 (Mus musculus)
Mcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 42 76.40 Quite High
imagery 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 50 100.00 Very High Very High Very High
Apoptosis 92 99.98 Very High Very High Very High
Repression 10 99.84 Very High Very High Very High
Metastasis 50 89.72 High High
Carcinoma 50 83.20 Quite High
Disease 4 77.48 Quite High
Cancer 36 72.16 Quite High
Death 14 51.08 Quite High
Adhesions 70 49.60 Quite Low
Breast Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies also identify previously uncharacterized interactions between CXCL12 and Bcl-2 family members in colorectal carcinomas through upregulation of Bim and downregulation of Mcl-1.
Bcl-2 Binding (interactions) of Mcl-1 associated with colon cancer
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.88 Pain Relevance 0.04
Anti-apoptotic Bcl-2 proteins such as Bcl-2, Mcl-1, and Bcl-XL heterodimerize with pro-apoptotic proteins to inhibit their function [8].
Bcl-2 Binding (heterodimerize) of Mcl-1 associated with apoptosis
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.26 Pain Relevance 0

General Comments

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