INT33327

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Context Info
Confidence 0.69
First Reported 1986
Last Reported 2011
Negated 3
Speculated 5
Reported most in Body
Documents 39
Total Number 46
Disease Relevance 9.68
Pain Relevance 18.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 10
forebrains 4
neuronal 4
pyramidal cells 2
embryos 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 1039 100.00 Very High Very High Very High
Dopamine 297 100.00 Very High Very High Very High
Neurotransmitter 152 100.00 Very High Very High Very High
Ventral tegmentum 96 100.00 Very High Very High Very High
GABA receptor 66 100.00 Very High Very High Very High
Morphine 7 99.98 Very High Very High Very High
nMDA receptor 28 99.76 Very High Very High Very High
Nicotine 11 99.52 Very High Very High Very High
amygdala 168 99.40 Very High Very High Very High
Gabapentin 80 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 264 99.92 Very High Very High Very High
Generalized Anxiety Disorder 18 99.70 Very High Very High Very High
Neuropathic Pain 48 99.56 Very High Very High Very High
Infantile Spasms 190 98.08 Very High Very High Very High
Schizophrenia 5 98.08 Very High Very High Very High
Disease 39 97.90 Very High Very High Very High
Aspiration Pneumonia 1 96.04 Very High Very High Very High
Neurodegenerative Disease 57 94.88 High High
Dysphagia 1 94.44 High High
Convulsion 155 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether gabapentin increased the expression of GABAA receptors, Western blots were stained with antibodies selective for alpha1, alpha2, and alpha5 subunits.
Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of GABAA
1) Confidence 0.69 Published 2006 Journal Anesthesiology Section Body Doc Link 16871066 Disease Relevance 0 Pain Relevance 0
Neither gabapentin nor vigabatrin increased the expression of GABAA receptors in the neurons.
Neg (Neither) Positive_regulation (increased) of Gene_expression (expression) of GABAA in neurons
2) Confidence 0.69 Published 2006 Journal Anesthesiology Section Body Doc Link 16871066 Disease Relevance 0 Pain Relevance 0
Anesthetic actions of GABAA receptors
Positive_regulation (actions) of Gene_expression (receptors) of GABAA
3) Confidence 0.49 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0 Pain Relevance 0.53
Although, GABAA receptors in the VTA does not mediate the increase in accumbal dopamine observed after food consumption induced by ghrelin (Kawahara et al. 2009).
Neg (not) Positive_regulation (mediate) of Gene_expression (receptors) of GABAA associated with ventral tegmentum and dopamine
4) Confidence 0.49 Published 2011 Journal Addiction Biology Section Body Doc Link PMC3015055 Disease Relevance 0.05 Pain Relevance 0.75
Finally, evidence has been shown that a tonic current mediated by GABAA receptors containing the ?
Positive_regulation (mediated) of Gene_expression (receptors) of GABAA
5) Confidence 0.49 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0 Pain Relevance 0.54
The pharmacodynamic effects of vigabatrin (inhibition of central and peripheral GABA-T and increase of brain GABA levels) remain after the drug has been eliminated from plasma (Bolton et al 1989).
Positive_regulation (increase) of Gene_expression (levels) of GABA in plasma associated with gaba
6) Confidence 0.42 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.24 Pain Relevance 0.39
On the other hand, bicuculline and picrotoxin antagonized not only GABA but also NE, whereas yohimbine counteracted not only NE but also GABA inhibition of ACh release, suggesting a close assembly of alpha-2 and GABAA receptors on the cholinergic axons.
Spec (suggesting) Positive_regulation (suggesting) of Gene_expression (assembly) of GABAA associated with gaba
7) Confidence 0.40 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3001287 Disease Relevance 0 Pain Relevance 0.35
In contrast, in nicotine-treated mice, morphine increased GABA levels in the presence of nipecotic acid.
Positive_regulation (increased) of Gene_expression (levels) of GABA associated with gaba, nicotine and morphine
8) Confidence 0.40 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18786163 Disease Relevance 0 Pain Relevance 1.58
The effect of GABA is not mediated through the simple cessation of neuronal spiking due to membrane hyperpolarization, because blocking neuronal spiking with TTX (1 ?
Neg (not) Positive_regulation (mediated) of Gene_expression (effect) of GABA in neuronal associated with tetrodotoxin and gaba
9) Confidence 0.39 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.62
The increased effectiveness of GABA as a modulator of retinal PER2 expression is likely due to the specific retinal expression of the GABAC receptor, which engenders nondesensitizing responses and prolongs greatly the effectiveness of any GABA stimulation [82–84].
Positive_regulation (increased) of Gene_expression (expression) of GABA associated with gaba
10) Confidence 0.39 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.07 Pain Relevance 0.55
For example, genes involved in the canonical pathway 'GABA-ergic signaling' (Slc32a1, Gabrg1 and Gad1) are closely correlated in the Red module, with increased expression levels in the amygdala.
Positive_regulation (increased) of Gene_expression (expression) of Gabrg1 in amygdala associated with gaba and amygdala
11) Confidence 0.39 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823687 Disease Relevance 0.47 Pain Relevance 0.54
Its mechanisms of action appear to be a complex synergy between increased GABA synthesis, non-NMDA receptor antagonism and binding to the ?
Positive_regulation (increased) of Gene_expression (synthesis) of GABA associated with gaba and nmda receptor
12) Confidence 0.39 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.14 Pain Relevance 0.80
The mechanisms of action of gabapentin, an analogue of GABA (Suman-Chauhan et al 1993), appear to be a complex synergy between increased GABA synthesis and function (Taylor et al 1998), non-NMDA receptor antagonism and binding to the ?
Positive_regulation (increased) of Gene_expression (synthesis) of GABA associated with gaba, nmda receptor and gabapentin
13) Confidence 0.39 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.22 Pain Relevance 0.96
If on one hand GABA action through GABAA receptors appears to be a key player in dendritic development, does GABAergic signaling also affect axonal morphological maturation?
Positive_regulation (through) of Gene_expression (receptors) of GABAA associated with gaba and gabaergic
14) Confidence 0.36 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.48
Gabapentin, a cyclic analogue of GABA, acts by enhancing GABA synthesis and also by decreasing neuronal calcium influx via a specific subunit of voltage-dependent calcium channels.
Positive_regulation (enhancing) of Gene_expression (synthesis) of GABA in neuronal associated with gaba, calcium channel and gabapentin
15) Confidence 0.35 Published 2001 Journal CNS Drugs Section Abstract Doc Link 11475940 Disease Relevance 0.15 Pain Relevance 1.08
The increased gene expression of GABA receptor subunits following loss of the ?
Positive_regulation (increased) of Gene_expression (expression) of GABA associated with gaba receptor
16) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.07 Pain Relevance 0.16
Replacements for GABAA receptor subunit composition during postnatal development under physiological conditions are well known.
Positive_regulation (Replacements) of Gene_expression (composition) of GABAA receptor subunit
17) Confidence 0.33 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0 Pain Relevance 0.04
Although qualitative in nature, these results further support the finding that GABAA receptor expression is increased in the ?
Positive_regulation (increased) of Gene_expression (expression) of GABAA receptor
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.05
Recent experiments have demonstrated that formation of functional type B gamma-aminobutyric acid (GABA(B)) receptors requires co-expression of two receptor subunits, GABA(B1) and GABA(B2).
Positive_regulation (requires) of Gene_expression (co-expression) of GABA in B gamma associated with gaba
19) Confidence 0.32 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747901 Disease Relevance 0 Pain Relevance 0.60
Furthermore, in schizophrenia patients there is a decrease in gamma-band activity (Cho et al., 2006) that is correlated with increased expression of the GABAA-receptor ?
Positive_regulation (increased) of Gene_expression (expression) of GABAA-receptor in band associated with schizophrenia
20) Confidence 0.32 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.40 Pain Relevance 0.19

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