INT333274

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tlr4) plasma membrane (Tlr4, Tlr4) intracellular (Tlr4, Tlr4)
cytoplasm (Tlr4, Tlr4) extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
immune cells 3
Tlr4 (Mus musculus)
Tlr4 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
chemokine 9 99.92 Very High Very High Very High
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Reprotox - General 3 3 92.56 High High
Chlamydia Infection 24 91.24 High High
Infection 5 87.96 High High
Bacterial Infection 3 5.00 Very Low Very Low Very Low
Peritonitis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of LPS to TLR4 on immune cells stimulates secretion of pro-inflammatory cytokines such as IL-6, chemokines such as CXCL1 and CCL20, and prostaglandin E2.
LPS Binding (Binding) of TLR4 in immune cells Positive_regulation (stimulates) of Localization (secretion) of IL-6 in immune cells associated with chemokine, inflammation and cytokine
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943929 Disease Relevance 0.59 Pain Relevance 0.23

General Comments

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