INT333278

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
embryos 2
5-HT neurons 2
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 42 94.80 High High
Serotonin 39 94.68 High High
antidepressant 5 92.40 High High
5HT 7 81.60 Quite High
medulla 15 37.68 Quite Low
Raphe 8 5.00 Very Low Very Low Very Low
Raphe magnus 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 2 79.76 Quite High
Sudden Infant Death Syndrome 6 78.72 Quite High
Hypoxia 1 76.00 Quite High
Rare Diseases 3 63.20 Quite High
Syndrome 4 62.56 Quite High
Targeted Disruption 5 61.32 Quite High
Hypercapnia 1 56.52 Quite High
Acidosis 57 50.00 Quite Low
Hypoventilation 2 33.52 Quite Low
Handedness 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sert mRNA levels were highly reduced in the VT retina of Zic2kd/kd embryos compared with WT littermates (Figure 3A).
Negative_regulation (reduced) of Transcription (levels) of Sert in embryos
1) Confidence 0.37 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Using mRNA hybridization and immunohistology, we also report SERT mRNA expression and a few 5-HT neurons in the vicinity of the RTN/pFRG area.
Negative_regulation (report) of Transcription (expression) of SERT in 5-HT neurons
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.56 Pain Relevance 0.36

General Comments

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