INT333283

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.17
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
ganglion cells 4
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 9 100.00 Very High Very High Very High
Pain 77 99.04 Very High Very High Very High
antagonist 5 70.04 Quite High
Cholecystokinin 3 60.08 Quite High
Thalamus 2 44.48 Quite Low
Serotonin 66 5.00 Very Low Very Low Very Low
Analgesic 23 5.00 Very Low Very Low Very Low
fluoxetine 20 5.00 Very Low Very Low Very Low
Opioid 13 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.70 Very High Very High Very High
Pain 80 99.04 Very High Very High Very High
Cancer 76 98.78 Very High Very High Very High
Pancreatic Cancer 17 50.00 Quite Low
Handedness 24 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Neuropathic Pain 9 5.00 Very Low Very Low Very Low
Skin Cancer 8 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The repeated administration of devazepide significantly suppressed the expression of the ephrin B1 gene compared with the vehicle-treated group in cancer-induced pain mice (p < 0.01) (Figure 6A); however, the gene expression of the Eph B1 receptor was unchanged in all of the test groups (Figure 6B).
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of Eph B1 receptor associated with pain, cancer and b1 receptor
1) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.97 Pain Relevance 0.47
The transcription factor Zic2 is expressed in uncrossed (iRGCs) but not in crossed (cRGCs) ganglion cells, and is necessary and sufficient to control the expression of the guidance receptor EphB1 (Herrera et al, 2003; Garcia-Frigola et al, 2008).
Positive_regulation (sufficient) of Gene_expression (expression) of EphB1 in ganglion cells associated with ganglion cysts
2) Confidence 0.29 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.10 Pain Relevance 0
The transcription factor Zic2 is expressed in uncrossed (iRGCs) but not in crossed (cRGCs) ganglion cells, and is necessary and sufficient to control the expression of the guidance receptor EphB1 (Herrera et al, 2003; Garcia-Frigola et al, 2008).
Positive_regulation (necessary) of Gene_expression (expression) of EphB1 in ganglion cells associated with ganglion cysts
3) Confidence 0.29 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.10 Pain Relevance 0

General Comments

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