INT333296

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
RNA binding (Gtf3a) plasma membrane (Slc6a4) nucleus (Gtf3a)
Anatomy Link Frequency
eye 2
neurons 2
Gtf3a (Mus musculus)
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 66 100.00 Very High Very High Very High
Raphe 8 93.88 High High
monoamine 4 62.56 Quite High
primary somatosensory cortex 2 53.28 Quite High
Thalamus 2 28.52 Quite Low
fluoxetine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 24 22.76 Low Low
Adhesions 2 22.64 Low Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Vibrio Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results presented here support this hypothesis and point to Zic2 as the first transcription factor that regulates Sert expression and serotonin homeostasis in non-aminergic neurons during development.


factor Regulation (regulates) of Gene_expression (expression) of Sert in neurons associated with serotonin
1) Confidence 0.01 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.66
Here, we report that the transcription factor Zic2 regulates directly the expression of the serotonin transporter (Sert) in iRGCs to refine eye-specific projections in primary visual targets.
factor Regulation (regulates) of Gene_expression (expression) of Sert in eye associated with serotonin
2) Confidence 0.01 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.08

General Comments

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