INT333299

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.17

endosome (Ephb1) cell differentiation (Zic2) signal transduction (Ephb1) cell adhesion (Ephb1) plasma membrane (Ephb1) nucleus (Zic2)

Zic2 (Mus musculus) Ephb1 (Mus musculus)

Pain Link Frequency Relevance Heat Raphe 4 83.28 Serotonin 33 82.08 monoamine 2 60.32 fluoxetine 10 5.00 primary somatosensory cortex 1 5.00 Thalamus 1 5.00

Disease Link Frequency Relevance Heat Handedness 12 87.40 Ganglion Cysts 3 5.00 Sprains And Strains 1 5.00 Vibrio Infection 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Together with previous results, this demonstrates that Zic2 determines the ipsilateral phenotype in the retinofugal pathway by regulating the transcription of at least two downstream effectors, EphB1 and Sert, which act sequentially at different steps of the maturation process in the visual pathway.

Zic2 Regulation (regulating) of Transcription (transcription) of EphB1

1) Confidence 0.50 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.09 Pain Relevance 0.17

General Comments

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