INT3333

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Context Info
Confidence 0.49
First Reported 1978
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 2.23
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PRSS1) extracellular space (PRSS1) extracellular region (PRSS1)
Anatomy Link Frequency
pancreas 2
cleavage 2
PRSS1 (Homo sapiens)
PRSS1 - E79K (1)
Pain Link Frequency Relevance Heat
Enkephalin 11 100.00 Very High Very High Very High
Dynorphin 7 99.50 Very High Very High Very High
Chronic pancreatitis 290 94.56 High High
anesthesia 1 25.00 Low Low
fibrosis 39 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Bile 18 5.00 Very Low Very Low Very Low
Pain management 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 4 100.00 Very High Very High Very High
Disease 73 95.60 Very High Very High Very High
Pancreatitis 377 94.56 High High
Targeted Disruption 27 62.00 Quite High
Hypertension 1 32.08 Quite Low
Pancreatic Cancer 48 5.00 Very Low Very Low Very Low
Cystic Fibrosis 36 5.00 Very Low Very Low Very Low
Pain 27 5.00 Very Low Very Low Very Low
Diabetes Mellitus 24 5.00 Very Low Very Low Very Low
Calcification 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
David Whitcomb proposed that the Arg122-Val123 autolytic peptide bond in trypsin plays an important role in the degradation of prematurely activated trypsin in the pancreas.
Positive_regulation (activated) of Protein_catabolism (degradation) of trypsin in pancreas
1) Confidence 0.49 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.59 Pain Relevance 0.14
R122H and increased trypsin stability
Positive_regulation (increased) of Protein_catabolism (stability) of trypsin
2) Confidence 0.46 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.60 Pain Relevance 0.15
The N29T mutant, firstly described by Pfützer et al. in 2002, exhibited a phenotype similar to that of R122H, both increased trypsin stability and enhanced autoactivation were documented [11,64].
Positive_regulation (increased) of Protein_catabolism (stability) of trypsin
3) Confidence 0.46 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.32 Pain Relevance 0
Although the E79K mutation introduces a potential new tryptic cleavage site, autocatalytic degradation (autolysis) of E79K-trypsin was also unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Protein_catabolism (degradation) of trypsin (E79K) in cleavage associated with autolysis
4) Confidence 0.40 Published 2004 Journal Hum. Mutat. Section Abstract Doc Link 14695529 Disease Relevance 0.72 Pain Relevance 0.12
The main dynorphin A peak at 5 kdalton was transferred to a major Leu-enkephalin-Arg6 peak by trypsin degradation.
Positive_regulation (transferred) of Protein_catabolism (degradation) of trypsin associated with dynorphin and enkephalin
5) Confidence 0.18 Published 1986 Journal Brain Res. Section Abstract Doc Link 2870778 Disease Relevance 0 Pain Relevance 0.88
In excess, the magnitude of which varies among individuals, trypsin at first produces activation and later a decline in PRA, probably due to degradation of the reactants (prorenin, renin, angiotensinogen) and of the initial product (angiotensin I).
Spec (probably) Positive_regulation (activation) of Protein_catabolism (degradation) of trypsin
6) Confidence 0.04 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 709420 Disease Relevance 0 Pain Relevance 0

General Comments

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