INT333301

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zic2) cytosol (Slc6a4) endosome (Slc6a4)
transport (Slc6a4) nucleus (Zic2) plasma membrane (Slc6a4)
Anatomy Link Frequency
retina 1
Slc6a4 (Mus musculus)
Zic2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 132 59.12 Quite High
fluoxetine 40 5.00 Very Low Very Low Very Low
Raphe 16 5.00 Very Low Very Low Very Low
monoamine 8 5.00 Very Low Very Low Very Low
primary somatosensory cortex 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 48 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Vibrio Infection 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that in 293HEK cells Zic2 increases the luciferase activity driven by the conserved region of the sert promoter, we determined whether Zic2 binds to this Sert regulatory sequence in the retina in vivo.
Sert Binding (binds) of Zic2 in retina
1) Confidence 0.47 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Thus, in order to further characterize the domain where Zic2 is binding inside the conserved 130 bp sert promoter, we mutated the Gli-binding site (Gli-BS).
sert Binding (binding) of Zic2
2) Confidence 0.47 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
The ChIP assays confirmed the specific binding of Zic2 to the 130-bp sequence located immediately upstream of the sert TSS.
sert Binding (binding) of Zic2
3) Confidence 0.35 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.03
This demonstrates that Zic2 is able to bind to this 130 bp-basic sert promoter region and activate transcription (Figure 4B).
sert Binding (bind) of Zic2
4) Confidence 0.35 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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