INT333302

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) cell differentiation (Zic2)
transport (Slc6a4) plasma membrane (Slc6a4) nucleus (Zic2)
Zic2 (Mus musculus)
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 99 98.22 Very High Very High Very High
fluoxetine 30 83.72 Quite High
Raphe 12 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
primary somatosensory cortex 3 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 36 59.76 Quite High
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Vibrio Infection 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the partial rescue of the Zic2 missexpression phenotype by blocking Sert demonstrates clearly that Zic2 upregulates Sert, which then inhibits the proper refinement and arborization of retinal axons at the colliculus.
Zic2 Positive_regulation (upregulates) of Sert
1) Confidence 0.68 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.40
However, neither of these mutations changed the ability of Zic2 to activate the sert promoter (Figure 4B).
Zic2 Positive_regulation (activate) of sert
2) Confidence 0.68 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Sert null mice that have accumulated serotonin extracellularly show a ‘lack-of-refinement' phenotype and mice that ectopically express Sert (induced by Zic2) exhibit similar alterations in the refinement process.
Zic2 Positive_regulation (induced) of Sert associated with serotonin
3) Confidence 0.49 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.11 Pain Relevance 0.17

General Comments

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