INT333303

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.47
Pain Relevance 0.91

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cytosol (Slc6a4) endosome (Slc6a4) cell differentiation (Zic2)
transport (Slc6a4) plasma membrane (Slc6a4) nucleus (Zic2)
Anatomy Link Frequency
eye 8
Zic2 (Mus musculus)
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 264 100.00 Very High Very High Very High
Raphe 32 95.12 Very High Very High Very High
fluoxetine 80 92.40 High High
monoamine 16 72.16 Quite High
Thalamus 8 28.24 Quite Low
primary somatosensory cortex 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 95.80 Very High Very High Very High
Handedness 96 94.56 High High
Adhesions 8 22.64 Low Low
Vibrio Infection 8 13.12 Low Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that Zic2 is able to regulate the expression of Sert in iRGCs in vivo by direct binding to its promoter region.


Zic2 Regulation (regulate) of Gene_expression (expression) of Sert
1) Confidence 0.60 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.04
On the basis of these findings and given that Zic2 controls Sert expression in iRGCs, we decided to examine whether Zic2 has a function in refinement at the visual targets.
Zic2 Regulation (controls) of Gene_expression (expression) of Sert
2) Confidence 0.60 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.04
Zic2 controls the transient expression of Sert during development
Zic2 Regulation (controls) of Gene_expression (expression) of Sert
3) Confidence 0.60 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.08 Pain Relevance 0.29
Here, we report that the transcription factor Zic2 regulates directly the expression of the serotonin transporter (Sert) in iRGCs to refine eye-specific projections in primary visual targets.
Zic2 Regulation (regulates) of Gene_expression (expression) of Sert in eye associated with serotonin
4) Confidence 0.26 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.08
Here, we report that, in addition, Zic2 controls the refinement of eye-specific inputs in the visual targets by regulating directly the expression of the serotonin transporter (Sert), which is involved in the modulation of activity-dependent mechanisms during the wiring of sensory circuits.
Zic2 Regulation (regulating) of Gene_expression (expression) of Sert in eye associated with serotonin
5) Confidence 0.26 Published 2010 Journal EMBO J Section Abstract Doc Link PMC2944059 Disease Relevance 0.10 Pain Relevance 0.09
Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets
Zic2 Regulation (regulates) of Gene_expression (expression) of Sert in eye
6) Confidence 0.26 Published 2010 Journal EMBO J Section Abstract Doc Link PMC2944059 Disease Relevance 0.05 Pain Relevance 0.04
Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets
Zic2 Regulation (regulates) of Gene_expression (expression) of Sert in eye
7) Confidence 0.26 Published 2010 Journal EMBO J Section Title Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.07
Together with previous results, these findings demonstrate that Zic2 controls specifically the refinement of ipsilateral but not contralateral axons in the primary visual targets by controlling directly the expression of Sert.


Zic2 Regulation (controlling) of Gene_expression (expression) of Sert
8) Confidence 0.26 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.17 Pain Relevance 0.25

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