INT333326

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.08
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bpa) cytoplasm (C4bpa)
Anatomy Link Frequency
bile 2
urine 1
hepatic vein 1
placenta 1
C4bpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 70 99.44 Very High Very High Very High
anesthesia 14 83.44 Quite High
Opioid 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 14 76.08 Quite High
Stress Incontinence 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M BPA-GA for 20 min to determine whether BPA-GA is transferred into the fetus across the placenta.
Localization (transferred) of BPA in placenta
1) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.13
Furthermore, BPA has been shown to be easily released from products.
Localization (released) of BPA
2) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
We previously reported that the excretion rate of BPA-GA from the liver into bile is decreased and that compensatory excretion of BPA-GA into the hepatic vein is increased in rodents during pregnancy (Inoue et al. 2004), and we hypothesize that this may also occur in humans.
Localization (excretion) of BPA in hepatic vein associated with bile
3) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05
Kurebayashi et al. (2003) showed that orally administered BPA is metabolized primarily into BPA-GA and that most BPA-GA is excreted in feces via bile, although some is excreted in urine.
Localization (excreted) of BPA in urine associated with bile
4) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.08 Pain Relevance 0.14
Bisphenol A (BPA), a well-known endocrine disruptor, is highly glucuronidated in the liver, and the resultant BPA-glucuronide (BPA-GA) is excreted primarily into bile.
Localization (excreted) of BPA in bile associated with bile
5) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05
Leaching of BPA out of the products is increased by heating (Krishnan et al. 1993), contact with alkaline substances (Olea et al. 1996), and deterioration of the products (Howdeshell et al. 2003), and BPA is thus widely released into the environment.
Localization (released) of BPA
6) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Bisphenol A (BPA), a well-known endocrine disruptor, is highly glucuronidated in the liver, and the resultant BPA-glucuronide (BPA-GA) is excreted primarily into bile.
Localization (excreted) of BPA in bile associated with bile
7) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05

General Comments

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