INT333393

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CFD, Timp1) peptidase activity (CFD) extracellular space (CFD)
aging (Timp1) proteinaceous extracellular matrix (Timp1)
CFD (Homo sapiens)
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 89.52 High High
fibrosis 55 81.92 Quite High
Inflammation 32 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 50 98.04 Very High Very High Very High
Nephrotoxicity 3 92.60 High High
Renal Disease 5 90.24 High High
Diabetes Mellitus 3 87.44 High High
Internal Fibrosis 16 81.92 Quite High
Proteinuria 2 69.76 Quite High
Renal Failure 1 28.40 Quite Low
Sclerosis 1 22.24 Low Low
Ureteral Obstruction 4 10.80 Low Low
Chronic Renal Failure 1 6.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PFD caused a decrease in collagen III and TIMP-1 mRNA expression, suggesting that it could attenuate the limited fibrotic potential of tacrolimus [62].
PFD Positive_regulation (caused) of Gene_expression (expression) of TIMP-1 mRNA associated with fibrosis
1) Confidence 0.07 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.82 Pain Relevance 0.16

General Comments

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