INT3334

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Context Info
Confidence 0.42
First Reported 1978
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 7 77.92 Quite High
anesthesia 1 25.00 Low Low
Angina 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 60 95.12 Very High Very High Very High
Pressure And Volume Under Development 13 58.08 Quite High
Cough 1 57.52 Quite High
Hypertension 5 34.80 Quite Low
Death 13 26.16 Quite Low
Renal Disease 26 5.00 Very Low Very Low Very Low
Diabetes Mellitus 19 5.00 Very Low Very Low Very Low
Stroke 18 5.00 Very Low Very Low Very Low
Cardiovascular Disease 13 5.00 Very Low Very Low Very Low
Heart Rate Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This may be due to the very high degree of renin┬ľangiotensin system activation in these patients, requiring a dual blockade to be fully reversed.
Positive_regulation (activation) of Protein_catabolism (degree) of renin
1) Confidence 0.42 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.61 Pain Relevance 0.07
In excess, the magnitude of which varies among individuals, trypsin at first produces activation and later a decline in PRA, probably due to degradation of the reactants (prorenin, renin, angiotensinogen) and of the initial product (angiotensin I).
Spec (probably) Positive_regulation (activation) of Protein_catabolism (degradation) of renin
2) Confidence 0.36 Published 1978 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 709420 Disease Relevance 0 Pain Relevance 0

General Comments

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