INT333509

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STON1, GPI) isomerase activity (GPI) small molecule metabolic process (GPI)
carbohydrate metabolic process (GPI) cytosol (GPI) extracellular space (GPI)
Anatomy Link Frequency
thalamus 1
STON1 (Homo sapiens)
GPI (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 31 98.40 Very High Very High Very High
Dopamine 8 84.92 Quite High
deep brain stimulation 57 25.28 Quite Low
Action potential 6 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 70 95.40 Very High Very High Very High
Parkinson's Disease 26 92.32 High High
Convulsion 2 48.40 Quite Low
Tremor 10 5.00 Very Low Very Low Very Low
Hypokinesia 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Burns 2 5.00 Very Low Very Low Very Low
Brain Disease 2 5.00 Very Low Very Low Very Low
Dyskinesias 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this static model, a decrease in inhibition to the striatum led to an increased activity of the STN, which increased excitation to the GPe and GPi, which increased the inhibition to the thalamus.
STN Positive_regulation (increased) of GPi in thalamus associated with thalamus
1) Confidence 0.04 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.49 Pain Relevance 0.12

General Comments

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