INT333515

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.38 Pain Relevance 0.40

cytoplasm (STON1)

STON1 (Homo sapiens)

Pain Link Frequency Relevance Heat deep brain stimulation 114 93.04 Action potential 12 80.44 imagery 4 78.80 Thalamus 62 55.28 depression 2 50.24 Neurotransmitter 6 44.40 Dopamine 16 36.28 Substantia nigra 8 5.00 palliative 4 5.00 Spinal cord 2 5.00

Disease Link Frequency Relevance Heat Disease 140 99.88 Convulsion 4 79.48 Depression 2 50.24 Parkinson's Disease 52 43.68 Tremor 20 5.00 Hypokinesia 10 5.00 Cognitive Disorder 6 5.00 Epilepsy 4 5.00 Burns 4 5.00 Brain Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

So, if increasing the frequency of GPi activity through stimulation of the STN had the same effect as burning a hole in the GPi, the reason had to lie in the dynamics of the effect of increasing the firing rate of the GPi.

Positive_regulation (increasing) of Positive_regulation (stimulation) of STN

1) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0 Pain Relevance 0.21

We have evidence of excessive activity of the GPi in Parkinson’s disease, but stimulation of the STN should further increase the GPi activity.

Positive_regulation (increase) of Positive_regulation (stimulation) of STN associated with disease

2) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.38 Pain Relevance 0.19

General Comments

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