INT333515

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (STON1)
STON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 114 93.04 High High
Action potential 12 80.44 Quite High
imagery 4 78.80 Quite High
Thalamus 62 55.28 Quite High
depression 2 50.24 Quite High
Neurotransmitter 6 44.40 Quite Low
Dopamine 16 36.28 Quite Low
Substantia nigra 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 140 99.88 Very High Very High Very High
Convulsion 4 79.48 Quite High
Depression 2 50.24 Quite High
Parkinson's Disease 52 43.68 Quite Low
Tremor 20 5.00 Very Low Very Low Very Low
Hypokinesia 10 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Burns 4 5.00 Very Low Very Low Very Low
Brain Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So, if increasing the frequency of GPi activity through stimulation of the STN had the same effect as burning a hole in the GPi, the reason had to lie in the dynamics of the effect of increasing the firing rate of the GPi.
Positive_regulation (increasing) of Positive_regulation (stimulation) of STN
1) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0 Pain Relevance 0.21
We have evidence of excessive activity of the GPi in Parkinson’s disease, but stimulation of the STN should further increase the GPi activity.
Positive_regulation (increase) of Positive_regulation (stimulation) of STN associated with disease
2) Confidence 0.13 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944387 Disease Relevance 0.38 Pain Relevance 0.19

General Comments

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