INT333544

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CTSB, APP) extracellular region (CTSB, APP) mitochondrion (CTSB)
Golgi apparatus (APP) intracellular (CTSB) extracellular matrix organization (APP)
Anatomy Link Frequency
cleavage 2
CTSB (Homo sapiens)
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 77 92.96 High High
imagery 12 9.00 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 14 94.60 High High
Targeted Disruption 3 69.52 Quite High
Disease 27 58.48 Quite High
Amyloid Plaque 7 53.84 Quite High
Dementia 2 23.12 Low Low
Cognitive Disorder 18 21.36 Low Low
INFLAMMATION 22 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There may be several mechanisms by which this occurs, either via modulation of APP cleavage by gamma secretase to favor production of shorter A?
secretase Regulation (modulation) of Protein_catabolism (cleavage) of APP in cleavage
1) Confidence 0.01 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2944647 Disease Relevance 0.53 Pain Relevance 0.62

General Comments

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