INT33358

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 24.18
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr1) plasma membrane (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
stomach 4
spike 2
synapse 2
epithelial cells 2
eosinophils 2
Cysltr1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 895 100.00 Very High Very High Very High
long-term potentiation 382 100.00 Very High Very High Very High
antagonist 255 100.00 Very High Very High Very High
Hippocampus 101 99.84 Very High Very High Very High
corticosteroid 235 99.74 Very High Very High Very High
Inflammation 338 99.68 Very High Very High Very High
withdrawal 236 99.60 Very High Very High Very High
Pyramidal cell 39 99.04 Very High Very High Very High
agonist 210 98.98 Very High Very High Very High
tolerance 119 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 895 100.00 Very High Very High Very High
INFLAMMATION 361 99.68 Very High Very High Very High
Respiratory Syncytial Virus 594 99.58 Very High Very High Very High
Contracture 5 99.48 Very High Very High Very High
Nociception 62 99.40 Very High Very High Very High
Targeted Disruption 616 99.32 Very High Very High Very High
Asthma 541 98.94 Very High Very High Very High
Infection 389 98.62 Very High Very High Very High
Rhinitis 186 98.32 Very High Very High Very High
Sinusitis 16 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The in vitro demonstration of up-regulated CysLT1 receptor expression with zafirlukast and montelukast would suggest a class effect, but several long-term clinical studies of montelukast have not suggested tolerance. [32] However, there are a number of reasons why tolerance could be masked: 1) it was not specifically looked for; 2) the population on average may not decline sufficiently for the effect to become clinically obvious, especially if improvements in a responsive sub-population counter-balance deteriorations in the remainder.
Gene_expression (expression) of CysLT1 receptor associated with tolerance
1) Confidence 0.62 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0.07 Pain Relevance 0.51
2-agonists and although speculative, perhaps ICS also affect CysLT1 receptor expression to explain the lesser evidence of tolerance to zafirlukast in the ICS treated group observed in our study, but this requires further investigation. [31]
Gene_expression (expression) of CysLT1 receptor associated with corticosteroid, tolerance and agonist
2) Confidence 0.62 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0.19 Pain Relevance 0.74
The leukotriene synthesis inhibitor zileuton and the leukotriene receptor antagonist zafirlukast have been shown to produce subjective and objective improvements in patients with mild to moderate asthma.
Gene_expression (produce) of leukotriene receptor associated with asthma and antagonist
3) Confidence 0.61 Published 2000 Journal Ear Nose Throat J Section Abstract Doc Link 10665187 Disease Relevance 0.63 Pain Relevance 0.10
The gene expression of CysLT(1)R but not 5-LOX was up-regulated in the stomach after I/R, but both expressions were increased under I/R in the presence of indomethacin.
Gene_expression (expression) of CysLT in stomach
4) Confidence 0.59 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20042530 Disease Relevance 0.14 Pain Relevance 0.19
Indomethacin alone caused a slight increase of CysLT(1)R expression and markedly up-regulated 5-LOX expression in the stomach.
Gene_expression (expression) of CysLT in stomach
5) Confidence 0.59 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20042530 Disease Relevance 0.13 Pain Relevance 0.15
We concluded that I/R up-regulated the expression of CysLT(1)R in the stomach; CysLTs play a role in the pathogenesis of I/R-induced gastric damage through the activation of CysLT(1)R; and the aggravation by indomethacin of these lesions may be brought about by the increase of CysLT production and the up-regulation of 5-LOX expression, in addition to the decreased prostaglandin production.
Gene_expression (expression) of CysLT in stomach
6) Confidence 0.52 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20042530 Disease Relevance 0.07 Pain Relevance 0.12
We concluded that I/R up-regulated the expression of CysLT(1)R in the stomach; CysLTs play a role in the pathogenesis of I/R-induced gastric damage through the activation of CysLT(1)R; and the aggravation by indomethacin of these lesions may be brought about by the increase of CysLT production and the up-regulation of 5-LOX expression, in addition to the decreased prostaglandin production.
Gene_expression (production) of CysLT in stomach
7) Confidence 0.52 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20042530 Disease Relevance 0.07 Pain Relevance 0.06
If LTD4 receptor expression is indeed up-regulated, then concomitant failure to reduce CysLT production by airway eosinophils could result in excessive receptor occupancy and activation on treatment withdrawal.
Gene_expression (expression) of LTD4 receptor in eosinophils associated with withdrawal
8) Confidence 0.48 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0.37 Pain Relevance 0.50
One potential explanation for the clinical deteriorations over time in those subjects receiving zafirlukast would be up-regulation of LTD4 receptor expression in the airways, including on smooth muscle cells, induced by chronic receptor occupation by the LRA.
Gene_expression (expression) of LTD4 receptor in smooth muscle cells associated with antagonist
9) Confidence 0.48 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0.30 Pain Relevance 0.33
If LTD4 receptor expression is indeed up-regulated, then concomitant failure to reduce CysLT production by airway eosinophils could result in excessive receptor occupancy and activation on treatment withdrawal.
Gene_expression (production) of CysLT in eosinophils associated with withdrawal
10) Confidence 0.48 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0.38 Pain Relevance 0.54
The importance of these observations is that they support the existence of dynamic cell-surface CysLT1 receptor expression and lend biological plausibility to our explanation for the loss of asthma control over time and rebound on LRA withdrawal. [28,29] Tachyphylaxis to ?
Gene_expression (expression) of CysLT1 receptor associated with asthma, antagonist and withdrawal
11) Confidence 0.48 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0.31 Pain Relevance 0.78
Sputum CysLT and PGE2 levels (Table 5)
Gene_expression (levels) of CysLT in Sputum
12) Confidence 0.47 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0 Pain Relevance 0.21
In vitro studies demonstrated that zymosan stimulates LTC4 synthesis by peritoneal cells whereas LTE4, LTD4, LTB4 or monoHETES were not detectable (using HPLC methods).
Neg (not) Gene_expression (detectable) of LTD4
13) Confidence 0.38 Published 1985 Journal Prostaglandins Section Abstract Doc Link 3001831 Disease Relevance 0.21 Pain Relevance 0.18
Cysteinyl leukotrienes were significantly elevated in both adult and weanling mice infected with RSV prior to influx of inflammatory cells at 7 d post infection (Figure 11), suggesting that epithelial cells were the main source. cysLT expression was detected earlier than PGE2, peaking at 5 d post infection in adult mice, and only elevated at 5 d in weanling mice.
Gene_expression (expression) of cysLT in epithelial cells associated with inflammation, infection and respiratory syncytial virus
14) Confidence 0.28 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.70 Pain Relevance 0.05
Airway epithelial cells, mast cells and alveolar macrophages are local sources of cysLT and PGE2, both of which have been shown to be elevated in the airways of children with bronchiolitis [66-68].
Gene_expression (sources) of cysLT in epithelial cells associated with respiratory syncytial virus
15) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.65 Pain Relevance 0.07
Although consistently detectable at 5 d post RSV in both age groups, cysLT levels varied markedly between animals.
Gene_expression (levels) of cysLT associated with respiratory syncytial virus
16) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.63 Pain Relevance 0.04
Prostaglandin E2 (PGE2), IL-13, vascular endothelial growth factor (VEGF) and cysteinyl leukotrienes (cysLT) were measured as potential mediators of airway hyperresponsiveness using enzyme immunoassay kits (PGE2, cysLT: Cayman Chemicals, MI, USA; IL-13, VEGF: Quantikine, R&D Systems, MN, USA) according the manufacturer's instructions.
Gene_expression (measured) of cysLT in PGE2
17) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.55 Pain Relevance 0.12
The LT modifiers comprise two pharmacologic classes of compounds, the leukotriene receptor antagonists (LTRAs) and the 5-lipoxygenase (5-LO) pathway inhibitors, or otherwise known as LT biosynthesis inhibitors.
Gene_expression (biosynthesis) of leukotriene receptor associated with antagonist
18) Confidence 0.16 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 0.33 Pain Relevance 0.05
Airway epithelial cells, mast cells and alveolar macrophages are local sources of cysLT and PGE2, both of which have been shown to be elevated in the airways of children with bronchiolitis [66-68].
Gene_expression (sources) of cysLT in mast cells associated with respiratory syncytial virus
19) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.65 Pain Relevance 0.07
Airway epithelial cells, mast cells and alveolar macrophages are local sources of cysLT and PGE2, both of which have been shown to be elevated in the airways of children with bronchiolitis [66-68].
Gene_expression (sources) of cysLT in alveolar macrophages associated with respiratory syncytial virus
20) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.65 Pain Relevance 0.07

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