INT333604

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 2.75
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF3) nucleoplasm (IRF3) plasma membrane (IRF3)
nucleus (IRF3) DNA binding (IRF3) cytoplasm (IRF3)
Anatomy Link Frequency
nucleus 3
epithelial cell 2
IRF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 11 96.32 Very High Very High Very High
cytokine 11 7.08 Low Low
anesthesia 22 5.00 Very Low Very Low Very Low
chemokine 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 187 94.60 High High
Bacterial Respiratory Disease 44 92.56 High High
Targeted Disruption 44 91.84 High High
Viral Infection 22 90.08 High High
Infection 297 88.96 High High
Disease 165 86.28 High High
Pyelonephritis 330 85.20 High High
Urinary Tract Infection 352 77.76 Quite High
Keloid Scars 22 76.80 Quite High
Carcinoma 11 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of the cells with a p38 inhibitor (SB202190) reduced the IL-8 response to r-ceramide (Figure 4E) and prevented nuclear translocation of IRF3 (Figure 4F, G).
Localization (translocation) of IRF3
1) Confidence 0.71 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0
IRF3 translocation to the nucleus in response to ceramide/TLR4
Localization (translocation) of IRF3 in nucleus
2) Confidence 0.71 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.07 Pain Relevance 0
In cells exposed to LPS+sCD14, the nuclear IRF3 translocation was weak (p>0.05 compared to control) and fewer dimers were formed after exposure to LPS+sCD14.
Localization (translocation) of IRF3
3) Confidence 0.71 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.05 Pain Relevance 0
By confocal microscopy (Figure 4A, C) we observed that r-ceramide triggered IRF3 translocation to the nucleus (p<0.001 compared to unstimulated cells, 90 min).
Localization (translocation) of IRF3 in nucleus
4) Confidence 0.71 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.06 Pain Relevance 0
The relevance of IRF3 to human pathology has not been investigated, however.
Localization (relevance) of IRF3
5) Confidence 0.66 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.68 Pain Relevance 0
IRF3 is an interferon regulatory transcription factor and following TLR4 activation, phosphorylated IRF3 homodimers translocate from the cytosol to the nucleus [43], [44], [45], [46].
Localization (translocate) of IRF3 in nucleus
6) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.07 Pain Relevance 0
E. coli S1918pap induced higher nuclear IRF3 translocation and IRF3 phosphorylation than E. coli S1918, consistent with results in ceramide-stimulated cells (Figure 5A and Figure S10, p<0.01 for a broader view).
Localization (translocation) of IRF3
7) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.23 Pain Relevance 0.04
We propose that ceramide interacts directly with TLR4, activates TRAM phosphorylation followed by nuclear translocation of IRF3.
Localization (translocation) of IRF3
8) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 1.09 Pain Relevance 0
There was less IRF3 translocation in response to E. coli S1918fim or to the non-fimbriated control E. coli S1918.
Localization (translocation) of IRF3
9) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.28 Pain Relevance 0.03
Bacterial fimbriae and IRF3 translocation in infected human renal tubular epithelial cells
Localization (translocation) of IRF3 in epithelial cells
10) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.15 Pain Relevance 0.05
We confirmed the results in a human bladder epithelial cell line (J82, Figure S6A) in which ceramide release caused rapid IRF3 translocation.
Localization (translocation) of IRF3 in epithelial cell
11) Confidence 0.62 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.05 Pain Relevance 0

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