INT333607

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.40
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF3) nucleoplasm (IRF3) plasma membrane (IRF3)
nucleus (IRF3) DNA binding (IRF3) cytoplasm (IRF3)
Anatomy Link Frequency
epithelial cell 2
nucleus 2
IRF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 77.48 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 68 95.20 Very High Very High Very High
Targeted Disruption 16 61.80 Quite High
Carcinoma 4 61.32 Quite High
Urinary Tract Infection 128 35.68 Quite Low
Infection 108 10.40 Low Low
Pyelonephritis 120 5.00 Very Low Very Low Very Low
Disease 60 5.00 Very Low Very Low Very Low
Abscess 28 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 16 5.00 Very Low Very Low Very Low
Bacteriuria 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By confocal microscopy (Figure 4A, C) we observed that r-ceramide triggered IRF3 translocation to the nucleus (p<0.001 compared to unstimulated cells, 90 min).
Positive_regulation (triggered) of Localization (translocation) of IRF3 in nucleus
1) Confidence 0.61 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.06 Pain Relevance 0
In cells exposed to LPS+sCD14, the nuclear IRF3 translocation was weak (p>0.05 compared to control) and fewer dimers were formed after exposure to LPS+sCD14.
Positive_regulation (nuclear) of Localization (translocation) of IRF3
2) Confidence 0.44 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.05 Pain Relevance 0
E. coli S1918pap induced higher nuclear IRF3 translocation and IRF3 phosphorylation than E. coli S1918, consistent with results in ceramide-stimulated cells (Figure 5A and Figure S10, p<0.01 for a broader view).
Positive_regulation (higher) of Localization (translocation) of IRF3
3) Confidence 0.41 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.23 Pain Relevance 0.04
We confirmed the results in a human bladder epithelial cell line (J82, Figure S6A) in which ceramide release caused rapid IRF3 translocation.
Positive_regulation (caused) of Localization (translocation) of IRF3 in epithelial cell
4) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.05 Pain Relevance 0

General Comments

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