INT333620

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF3) nucleoplasm (IRF3) plasma membrane (IRF3)
nucleus (IRF3) DNA binding (IRF3) cytoplasm (IRF3)
IRF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 2 65.32 Quite High
cytokine 2 64.48 Quite High
agonist 2 40.56 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 6 98.00 Very High Very High Very High
Disease Susceptibility 4 90.08 High High
Pyelonephritis 60 78.68 Quite High
Bacteriuria 8 71.92 Quite High
Bacterial Infection 4 65.68 Quite High
Urinary Tract Infection 64 64.12 Quite High
Fever 6 59.80 Quite High
Disease 30 57.28 Quite High
Renal Disease 6 51.12 Quite High
Infection 54 47.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that ceramide-induced TLR4 signaling causes rapid phosphorylation/transcription of proteins involved in IRF3 and AP-1 transcription, including CREB, Fyn, PLC?
Transcription (transcription) of IRF3
1) Confidence 0.63 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0.03
It was speculated that the A-C haplotype increased IRF3 transcription and that the G-T haplotype might protect against SLE by reducing type I IFN production.
Transcription (transcription) of IRF3 associated with systemic lupus erythematosus
2) Confidence 0.47 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 1.12 Pain Relevance 0.03

General Comments

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