INT333625

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.49
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF3) nucleoplasm (IRF3) plasma membrane (IRF3)
nucleus (IRF3) DNA binding (IRF3) cytoplasm (IRF3)
Anatomy Link Frequency
internal 1
IRF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 68.24 Quite High
agonist 59 58.00 Quite High
Inflammation 73 47.20 Quite Low
cytokine 56 46.16 Quite Low
chemokine 15 8.56 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Bile 11 5.00 Very Low Very Low Very Low
tolerance 11 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urinary Tract Infection 160 98.92 Very High Very High Very High
Sprains And Strains 91 97.80 Very High Very High Very High
Infection 187 90.76 High High
Bacterial Respiratory Disease 24 89.12 High High
Viral Infection 12 88.92 High High
Disease 89 85.64 High High
Pyelonephritis 150 84.08 Quite High
Targeted Disruption 24 82.72 Quite High
Abscess 35 80.80 Quite High
Bacteriuria 20 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this model, IRF3 activation was not controlled by PKC dependent mechanisms, however.
Positive_regulation (activation) of IRF3
1) Confidence 0.61 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.35 Pain Relevance 0.03
We show that IRF3 is activated in a pathogen-specific manner by P-fimbriated, uropathogenic E. coli, through a new signaling pathway involving TLR4, TRAM, CREB and p38.
Positive_regulation (activated) of IRF3
2) Confidence 0.61 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.72 Pain Relevance 0
To examine if UTI susceptibility is associated with differences in IRF3 promoter efficiency, IRF3 promoter sequence variation was studied in two highly UTI-prone patient populations.
Positive_regulation (variation) of IRF3 associated with urinary tract infection
3) Confidence 0.44 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 1.34 Pain Relevance 0
The cells were transiently transfected with wild type or mutant IRF3 promoter driven firefly luciferase constructs (pGL3) together with a constitutively expressed internal control construct with Renilla luciferase-thymidine kinase promoter (pRL-TK, Promega) using Fugene HD (Roche) Transfection reagent at 4?
Positive_regulation (driven) of IRF3 in internal
4) Confidence 0.44 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.06 Pain Relevance 0
As a consequence of this selective IRF3 activation, the uropathogenic or P-fimbriated, commensal E. coli strains influenced epithelial gene transcription in a pathogen-specific manner.
Positive_regulation (activation) of IRF3 associated with sprains and strains
5) Confidence 0.41 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.61 Pain Relevance 0
through activation of interferon regulatory factor 3 (IRF3) [80].
Positive_regulation (activation) of IRF3
6) Confidence 0.13 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.30 Pain Relevance 0
via MyD88-independent IRF3 activation [13].
Positive_regulation (activation) of IRF3
7) Confidence 0.13 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.11 Pain Relevance 0.06

General Comments

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