INT333630

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0

cytoplasm (Tlr4, IRF3) plasma membrane (Tlr4, IRF3) nucleoplasm (IRF3) intracellular (Tlr4) DNA binding (IRF3) cytosol (IRF3)

Tlr4 (Mus musculus) IRF3 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1 18.56 anesthesia 2 5.00 addiction 1 5.00 cytokine 1 5.00 chemokine 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 4 98.36 Sprains And Strains 17 97.08 Viral Infection 2 82.92 Infection 27 65.88 Bacteriuria 4 57.60 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 9.80 Pseudomonas Infection 1 9.60 Vibrio Infection 1 7.04 Urinary Tract Infection 32 5.00 Pyelonephritis 30 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IRF3 phosphorylation in response to ceramide was controlled by TLR4 and TRAM, as shown using specific siRNA knock down.

TLR4 Regulation (controlled) of Phosphorylation (phosphorylation) of IRF3 associated with targeted disruption

1) Confidence 0.39 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.59 Pain Relevance 0

General Comments

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