INT333687

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Trp53, Bcl2) nucleus (Trp53, Bcl2) endoplasmic reticulum (Trp53, Bcl2)
cytoplasm (Trp53, Bcl2) cytosol (Trp53, Bcl2) transcription factor binding (Trp53, Bcl2)
Trp53 (Mus musculus)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 78 100.00 Very High Very High Very High
Targeted Disruption 29 95.08 Very High Very High Very High
Injury 2 82.64 Quite High
Huntington's Chorea 1 77.60 Quite High
Stress 10 75.40 Quite High
Urological Neuroanatomy 3 26.88 Quite Low
Death 8 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Alopecia 2 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chemically damaged cells undergo a p53-dependent apoptotic pathway that involves upregulation of p53 transcripts such as the pro-apoptotic Bcl2 family members and p53 translocation to the mitochondria, resulting in neutralization of the anti-apoptotic members Bcl-xL and Bcl-2 [26].
p53 Positive_regulation (upregulation) of Localization (translocation) of Bcl2 associated with apoptosis
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.24 Pain Relevance 0

General Comments

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