INT333689

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Hr, Trp53) nucleus (Hr, Trp53) nucleoplasm (Trp53)
mitochondrion (Trp53) endoplasmic reticulum (Trp53) enzyme binding (Trp53)
Anatomy Link Frequency
nucleus 4
Hr (Mus musculus)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 156 98.96 Very High Very High Very High
Targeted Disruption 58 87.12 High High
Huntington's Chorea 2 77.96 Quite High
Injury 4 74.96 Quite High
Stress 20 35.64 Quite Low
Death 16 5.00 Very Low Very Low Very Low
Necrosis 8 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Alopecia 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One possibility is that Hr decreases levels of p53 by promoting p53 degradation through a proteosome dependent pathway. p53 has previously been shown to be deacetylated through formation of a complex with the E3 ligase MDM2[31], [32], [33], and histone deacetylates (HDAC), for example HDAC1[34], resulting in proteosomal degradation of p53 [35], or p53 export from nucleus[36].
Hr Positive_regulation (promoting) of Protein_catabolism (degradation) of p53 in nucleus
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.86 Pain Relevance 0
One possibility is that Hr decreases levels of p53 by promoting p53 degradation through a proteosome dependent pathway. p53 has previously been shown to be deacetylated through formation of a complex with the E3 ligase MDM2[31], [32], [33], and histone deacetylates (HDAC), for example HDAC1[34], resulting in proteosomal degradation of p53 [35], or p53 export from nucleus[36].
Hr Positive_regulation (promoting) of Protein_catabolism (degradation) of p53 in nucleus
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 0.86 Pain Relevance 0

General Comments

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