INT333744

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.80
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr10) plasma membrane (Ccr10) signal transducer activity (Ccr10)
Anatomy Link Frequency
T cells 2
Ccr10 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 14 91.32 High High
Inflammation 46 89.72 High High
Central nervous system 88 78.24 Quite High
Multiple sclerosis 49 71.40 Quite High
fibrosis 3 46.96 Quite Low
cytokine 49 45.16 Quite Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 8 99.12 Very High Very High Very High
Hyperplasia 4 92.64 High High
INFLAMMATION 47 89.72 High High
Targeted Disruption 10 87.92 High High
Death 16 84.36 Quite High
Apoptosis 5 83.64 Quite High
Central Nervous System Disease 84 78.24 Quite High
Multiple Sclerosis 201 71.40 Quite High
Autoimmune Disease 27 67.44 Quite High
Airway Remodeling 6 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since one recent study also showed that vitamin D3 induces the expression of CCR10 on activated CD4+ T cells in the presence of IL-12 [57], we investigated the possibility that vitamin D3 also plays a role in the ability of TH17 cells to express CCR10 instead of CCR6.
Gene_expression (expression) of CCR10 in T cells
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.70 Pain Relevance 0.26
Overall, we found that vitamin D3 down-regulates CCR6 but not CCR10 expression in the TH17-conditioned circumstance.
Gene_expression (expression) of CCR10
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.43 Pain Relevance 0.13
Those investigations showed that 1,25(OH)2D3 did not induce CCR10 expression on the TH17 cells in the presence of TGF-?
Gene_expression (expression) of CCR10
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.56 Pain Relevance 0.22
Since one recent study also showed that vitamin D3 induces the expression of CCR10 on activated CD4+ T cells in the presence of IL-12 [57], we investigated the possibility that vitamin D3 also plays a role in the ability of TH17 cells to express CCR10 instead of CCR6.
Gene_expression (express) of CCR10 in T cells
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.53 Pain Relevance 0.24
In contrast, overexpression of IL-4 using the CC-10 promoter resulted in baseline eosinophilia without AHR [50].
Gene_expression (overexpression) of CC-10 promoter associated with eosinophilia
5) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

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